| Gene Symbol |
PPP1R13L
|
| Entrez Gene |
10848
|
| Alt Symbol |
IASPP, NKIP1, RAI, RAI4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 1, regulatory subunit 13 like
|
| Other Description |
NFkB interacting protein 1|NFkB-interacting protein 1|PPP1R13B-like protein|inhibitor of ASPP protein|inhibitor of apoptosis stimulating protein of p53|protein iASPP|protein phosphatase 1, regulatory (inhibitor) subunit 13 like|relA-associated inhibitor|retinoic acid induced 4
|
| Swissprots |
Q9Y290 Q2PNZ9 Q8WUF5 Q6PKF8 Q5DU71 Q6P1R7 Q5I1X4
|
| Accessions |
ABC40745 EAW57343 EAW57344 EAW57345 Q8WUF5 AF078036 AAD27004 AF078037 AAD27005 AJ888472 CAI60219 AK130326 BAC85327 AY869712 AAW51146 BC001475 AAH01475 BC014499 BC020259 BC020589 AAH20589 BC032298 AAH32298 BC064913 AAH64913 DB209153 DQ986418 ABK76301 NM_001142502 NP_001135974 NM_006663 NP_006654
|
| Function |
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear.
|
| Tissue Specificity |
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. {ECO:0000269|PubMed:10336463}.
|