Gene Symbol | PPP1R13L |
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Entrez Gene | 10848 |
Alt Symbol | IASPP, NKIP1, RAI, RAI4 |
Species | Human |
Gene Type | protein-coding |
Description | protein phosphatase 1, regulatory subunit 13 like |
Other Description | NFkB interacting protein 1|NFkB-interacting protein 1|PPP1R13B-like protein|inhibitor of ASPP protein|inhibitor of apoptosis stimulating protein of p53|protein iASPP|protein phosphatase 1, regulatory (inhibitor) subunit 13 like|relA-associated inhibitor|retinoic acid induced 4 |
Swissprots | Q9Y290 Q2PNZ9 Q8WUF5 Q6PKF8 Q5DU71 Q6P1R7 Q5I1X4 |
Accessions | ABC40745 EAW57343 EAW57344 EAW57345 Q8WUF5 AF078036 AAD27004 AF078037 AAD27005 AJ888472 CAI60219 AK130326 BAC85327 AY869712 AAW51146 BC001475 AAH01475 BC014499 BC020259 BC020589 AAH20589 BC032298 AAH32298 BC064913 AAH64913 DB209153 DQ986418 ABK76301 NM_001142502 NP_001135974 NM_006663 NP_006654 |
Function | Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. {ECO:0000269|PubMed:10336463, ECO:0000269|PubMed:12134007, ECO:0000269|PubMed:12524540, ECO:0000269|PubMed:15489900}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly cytoplasmic but also nuclear. |
Tissue Specificity | Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte. {ECO:0000269|PubMed:10336463}. |
Human iASPP full length protein - ab153136 from Abcam
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Human iASPP protein fragment - ab153137 from Abcam
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Recombinant Human iASPP Protein - H00010848-Q01 from Novus Biologicals
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Recombinant Human iASPP Protein - H00010848-P01 from Novus Biologicals
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PPP1R13L - H00010848-P01 from Acris Antibodies
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PPP1R13L - H00010848-Q01-10 from Acris Antibodies
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PPP1R13L - H00010848-Q01-25 from Acris Antibodies
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PPP1R13L fusion protein - Ag13273 from Proteintech Group
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PPP1R13L fusion protein - ag0635 from Proteintech Group
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Recombinant Human PPP1R13L, His-tagged - PPP1R13L-1903H from Creative Biomart
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Recombinant Human RelA-associated inhibitor(PPP1R13L) ,partial - CSB-YP851965HU CSB-EP851965HU CSB-BP851965HU CSB-MP851965HU from Cusabio
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iASPP Protein - NBP2-38879PEP from Novus Biologicals
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iASPP Recombinant Protein Antigen - NBP2-48732PEP from Novus Biologicals
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PPP1R13L-Blocking-Peptide-Center - BP21505c from Abgent, a WuXi AppTec company
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PPP1R13L-Blocking-Peptide-N-Term - BP21503a from Abgent, a WuXi AppTec company
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PPP1R13L Peptide, Human - M34GP12235H from Creative Peptides
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RelA-associated inhibitor (PPP1R13L), partial, Recombinant Protein - MBS1453777 from MyBioSource
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