| Gene Symbol |
RNF139
|
| Entrez Gene |
11236
|
| Alt Symbol |
HRCA1, RCA1, TRC8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 139
|
| Other Description |
E3 ubiquitin-protein ligase RNF139|multiple membrane spanning receptor TRC8|patched related protein translocated in renal cancer|translocation in renal carcinoma on chromosome 8 protein
|
| Swissprots |
B3KMD5 Q8WU17 Q7LDL3 O75485
|
| Accessions |
AAC39931 CAH56830 EAW92064 Q8WU17 AA455970 AF064801 AAC39930 AK001602 BAG50947 AK025043 AK098519 BC021571 AAH21571 BC064636 AAH64636 BI562637 BM677460 BM804626 CD171728 NM_007218 NP_009149
|
| Function |
E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
|
| Tissue Specificity |
Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney. {ECO:0000269|PubMed:9689122}.
|