RNF139

Gene Symbol	RNF139
Entrez Gene	11236
Alt Symbol	HRCA1, RCA1, TRC8
Species	Human
Gene Type	protein-coding
Description	ring finger protein 139
Other Description	E3 ubiquitin-protein ligase RNF139|multiple membrane spanning receptor TRC8|patched related protein translocated in renal cancer|translocation in renal carcinoma on chromosome 8 protein
Swissprots	B3KMD5 Q8WU17 Q7LDL3 O75485
Accessions	AAC39931 CAH56830 EAW92064 Q8WU17 AA455970 AF064801 AAC39930 AK001602 BAG50947 AK025043 AK098519 BC021571 AAH21571 BC064636 AAH64636 BI562637 BM677460 BM804626 CD171728 NM_007218 NP_009149
Function	E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
Tissue Specificity	Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney. {ECO:0000269|PubMed:9689122}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF139 full length protein - ab161365 from Abcam Category Protein Source Wheat germ Species Human

Human RNF139 protein fragment - ab161366 from Abcam Category Protein Source Wheat germ Species Human

RNF139 / TRC8 Antibody Blocking Peptide - LS-E25521 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF139 / TRC8 Antibody Blocking Peptide - LS-E15864 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF139 Protein - H00011236-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF139 Protein - H00011236-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRC8 blocking peptide - GTX88450-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog

RNF139 Blocking Peptide - 33R-8723 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF139 Peptide - AC21-0350-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF139 - H00011236-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF139 - H00011236-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF139 - H00011236-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF139 - H00011236-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRC8 Peptide - 46-933P from ProSci Category Peptide Species Human

TRC8, Peptide - MBS426540 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Dog

RNF139 Recombinant Protein Antigen - NBP1-83212PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF139-Blocking-Peptide-C-Term - BP21873b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF139 Peptide, Human - M34GP13385H from Creative Peptides Category Peptide Source Synthetic. Species Human

RNF139 fusion protein - Ag27147 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

RNF139 Immunizing peptide - orb55120 from Biorbyt Category Peptide

Search more