RNF139

Gene Symbol RNF139
Entrez Gene 11236
Alt Symbol HRCA1, RCA1, TRC8
Species Human
Gene Type protein-coding
Description ring finger protein 139
Other Description E3 ubiquitin-protein ligase RNF139|multiple membrane spanning receptor TRC8|patched related protein translocated in renal cancer|translocation in renal carcinoma on chromosome 8 protein
Swissprots B3KMD5 Q8WU17 Q7LDL3 O75485
Accessions AAC39931 CAH56830 EAW92064 Q8WU17 AA455970 AF064801 AAC39930 AK001602 BAG50947 AK025043 AK098519 BC021571 AAH21571 BC064636 AAH64636 BI562637 BM677460 BM804626 CD171728 NM_007218 NP_009149
Function E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
Tissue Specificity Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney. {ECO:0000269|PubMed:9689122}.

TRC8 (E-12) - sc-376358 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRC8 (E-12): sc-376358. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic staining of cells in seminiferous ducts and Leydig cells.

TRC8 (H-9) - sc-390347 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRC8 (H-9): sc-390347. Western blot analysis of TRC8 expression in non-transfected: sc-117752 (A) and human TRC8 transfected: sc-116907 (B) 293T whole cell lysates.

TRC8 (H-89) - sc-68373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRC8 (H-89): sc-68373. Western blot analysis of TRC8 expression in non-transfected 293T: sc-117752 (A), human TRC8 transfected 293T: sc-116907 (B) and Hep G2 (C) whole cell lysates.

TRC8 (S-17) - sc-67885 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TRC8 (S-17): sc-67885. Western blot analysis of TRC8 expression in non-transfected: sc-117752 (A) and human TRC8 transfected: sc-116907 (B) 293T whole cell lysates.

TRC8 (YB-16) - sc-101115 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
TRC8 (YB-16): sc-101115. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human tonsil tissue showing membrane and cytoplasmic localization.

Anti-RNF139 antibody - ab56924 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
RNF139 antibody (ab56924) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human tonsil.

Anti-RNF139 antibody - ab82647 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RNF139 antibody (ab82647) at 1 µg/ml (in 5% skim milk / PBS buffer) + MCF7 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-RNF139 antibody - C-terminal - ab189173 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-RNF139 antibody - C-terminal (ab189173) at 0.5 µg/ml + Human skeletal muscle cell lysate in RIPA buffer at 35 µg/mldeveloped using the ECL technique

Anti-RNF139 / TRC8 Antibody (Internal) - LS-C153494 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-RNF139 / TRC8 Antibody (aa565-665, Azide-free) - LS-C330694 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-RNF139 / TRC8 Antibody (clone 3D10) - LS-C133685 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
RNF139 monoclonal antibody (M01), clone 3D10 Western blot of RNF139 expression in HepG2.

Anti-RNF139 / TRC8 Antibody (aa651-663) IHC-plus™ - LS-B8293 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-RNF139 / TRC8 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8293 dilution 3.75 ug/ml.

Anti-RNF139 / TRC8 Antibody (aa72-121) IHC-plus™ - LS-B8095 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RNF139 / TRC8 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8095 dilution 5-10 ug/ml.

RNF139 Antibody (3D10) - H00011236-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
Western Blot: RNF139 Antibody (3D10) [H00011236-M01] - Western Blot analysis of RNF139 expression in HepG2 ( Cat # L019V1 ).

RNF139 Antibody - NBP1-23027 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: RNF139 Antibody [NBP1-23027] - (1ug/ml) staining of Human Skeletal Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

RNF139 Antibody - NBP1-59756 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RNF139 Antibody [NBP1-59756] - Titration: 0.2-1 ug/ml, Positive Control: MCF7 cell lysate.

RNF139 Antibody - H00011236-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

RNF139 Antibody - NBP1-83212 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RNF139 Antibody [NBP1-83212] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

RNF139 Polyclonal Antibody - bs-6096R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-RNF139 antibody produced in mouse - WH0011236M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
<B>Immunoblotting</B><BR/>Monoclonal Anti-RNF139, <B>Cat. No. WH0011236M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~75.9 kDa using HepG2 lysate.

Anti-RNF139 (C-terminal) antibody produced in goat - SAB2501144 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RNF139 (C-terminal): <B>Cat. No. SAB2501144</B>: (0.5 μg/mL) staining of Human Skeletal muscle lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-RNF139 antibody produced in rabbit - HPA001202 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RNF139: <B>Cat. No. HPA001202</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes.

RNF139 antibody - N-terminal region (ARP43092_P050) - ARP43092_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF139-Antibody-monoclonal-M01 - AT3665a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D10
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) .

TRC8-Antibody - AF2108a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2108a (1 µg/ml) staining of Human Skeletal Muscle lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Search more