RNF139

Gene Symbol RNF139
Entrez Gene 11236
Alt Symbol HRCA1, RCA1, TRC8
Species Human
Gene Type protein-coding
Description ring finger protein 139
Other Description E3 ubiquitin-protein ligase RNF139|multiple membrane spanning receptor TRC8|patched related protein translocated in renal cancer|translocation in renal carcinoma on chromosome 8 protein
Swissprots B3KMD5 Q8WU17 Q7LDL3 O75485
Accessions AAC39931 CAH56830 EAW92064 Q8WU17 AA455970 AF064801 AAC39930 AK001602 BAG50947 AK025043 AK098519 BC021571 AAH21571 BC064636 AAH64636 BI562637 BM677460 BM804626 CD171728 NM_007218 NP_009149
Function E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms involving G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER). Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination. May be required for EIF3 complex ubiquitination. May function as a signaling receptor. {ECO:0000269|PubMed:10500182, ECO:0000269|PubMed:12032852, ECO:0000269|PubMed:17016439, ECO:0000269|PubMed:19706601, ECO:0000269|PubMed:19720873, ECO:0000269|PubMed:20068067}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12032852}; Multi-pass membrane protein {ECO:0000269|PubMed:12032852}.
Tissue Specificity Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney. {ECO:0000269|PubMed:9689122}.

TRC8 CRISPR/Cas9 KO Plasmid (h) - sc-403689 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 HDR Plasmid (h) - sc-403689-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 Double Nickase Plasmid (h) - sc-403689-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 Double Nickase Plasmid (h2) - sc-403689-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 CRISPR Activation Plasmid (h) - sc-403689-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 CRISPR Activation Plasmid (h2) - sc-403689-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 Lentiviral Activation Particles (h) - sc-403689-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 Lentiviral Activation Particles (h2) - sc-403689-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRC8 siRNA (h) - sc-63155 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRC8 shRNA Plasmid (h) - sc-63155-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRC8 shRNA (h) Lentiviral Particles - sc-63155-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF139 RNAi - H00011236-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU052911 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18384 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18384 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07784 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr07784

RNF139 siRNA (Human) - CRH7701 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF139 - MBS8233384 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF139 (NM_007218.3) - SHH396736 from Creative biogene

Category siRNA
Species Reactivities Human

RNF139 shRNA Plasmid (Human) - CHH7701 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF139 miRNA 3'UTR clone - MiUTR1H-08880 from Creative biogene

Species Reactivities Human
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