KDM1A

Gene Symbol KDM1A
Entrez Gene 23028
Alt Symbol AOF2, BHC110, KDM1, LSD1
Species Human
Gene Type protein-coding
Description lysine (K)-specific demethylase 1A
Other Description BRAF35-HDAC complex protein BHC110|FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit|amine oxidase (flavin containing) domain 2|flavin-containing amine oxidase domain-containing protein 2|lysine (K)-specific demethylase 1|lysine-specific histone demethylase 1|lysine-specific histone demethylase 1A
Swissprots Q5TH94 Q5TH95 O60341 Q8IXK4 A8MWP9 Q86VT7 Q96AW4 Q8TAZ3 Q8NDP6
Accessions CBY79414 CBY88366 EAW95031 EAW95032 EAW95033 O60341 AA664447 AB011173 BAA25527 AK128669 AK290328 BAF83017 AL833812 CAD38675 BC016639 AAH16639 BC025362 AAH25362 BC040194 AAH40194 BC048134 AAH48134 BG717076 BQ006926 XM_005245786 XP_005245843 XM_006710472 XP_006710535 XM_006710473 XP_006710536 XM_006710474 XP_006710537 NM_001009999 NP_001009999 NM_015013 NP_055828
Function Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag tha
Subcellular Location Nucleus {ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:16079795}.
Tissue Specificity Ubiquitously expressed. {ECO:0000269|PubMed:16079795}.

Histone Demethylase KDM1/LSD1 Activity Quantification Assay Kit - ab113457 from Abcam

Category Cellular Assay
Prices $330.00, $546.00
Sizes 48 tests, 96 tests
LSD1 activity measured from NIH-3T3 cell extracts.

Histone Demethylase KDM1/LSD1 Inhibitor Assay Kit - ab113456 from Abcam

Category Cellular Assay
Prices $191.00, $361.00
Sizes 48 tests, 96 tests
Inhibition of KDM1/LSD1 by tranylcypromine (TCP) detected using ab113456. [LSD1 concentration: 500 ng/well].

KDM1/LSD1 Activity Quantification Assay Kit (Colorimetric) - ab113459 from Abcam

Category Cellular Assay
Prices $433.00, $659.00
Sizes 48 tests, 96 tests
Demonstration of inhibitory effects of an KDM1/LSD1 inhibitor detected by ab113459. [LSD1 concentration: 200 ng/well]

KDM1/LSD1 Activity Quantification Assay Kit (Fluorometric) - ab113460 from Abcam

Category Cellular Assay
Prices $433.00, $659.00
Sizes 48 tests, 96 tests
Demonstration of inhibitory effects of a KDM1/LSD1 inhibitor detected by ab113460. [KDM1/LSD1 concentration: 200 ng/well].

LSD1 Fluorometric Assay Kit - KA0576 from Novus Biologicals

Category Assay Kit
Prices $659.00
Sizes 1 kit

LSD1 Fluorometric Assay Kit - KA0575 from Novus Biologicals

Category Assay Kit
Prices $599.00
Sizes 1 kit

LSD1 Fluorometric Assay Kit - KA0573 from Novus Biologicals

Category Assay Kit
Prices $799.00
Sizes 1 kit

LSD1 Fluorometric Assay Kit - KA1603 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

LSD1 Assay/Inhibitor Screening Assay Kit - KA1548 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

LSD1 Assay/Inhibitor Screening Assay Kit - KA1525 from Novus Biologicals

Category Assay Kit
Prices $519.00
Sizes 1 kit

AOF2 (Human) IP-WB Antibody Pair - H00023028-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Human Lysine-specific histone demethylase 1A ELISA Kit - EKE53232 from Biomatik

Category ELISA Kit
Prices $685.40, $2,912.95, $5,483.20
Sizes 96 t, 5x96t, 10x96t
Range 0.312-20 ng/ml

Human KDM1A ELISA Kit - E023206 from Biobool

Category ELISA Kit

KDM1A ELISA Kit (Human) (OKEH03137) - OKEH03137 from Aviva Systems Biology

Category ELISA Kit
Prices $425.00
Sizes 96 wells
Sensitivity 0.156 ng/mL
Range 0.312 - 20 ng/mL

Human Lysine-specific histone demethylase 1A ELISA Kit - EK3138 from Signalway Antibody

Category ELISA Kit
Prices $599.00
Sizes 1x96t
Range 0.312-20 ng/ml

anti-KDM1 / LSD1 antibody - ARG53984 from Arigo Biolaboratories

Category ELISA Kit

Lysine-specific histone demethylase 1A, ELISA Kit - MBS9426972 from MyBioSource

Category ELISA Kit
Prices $555.00
Sizes 96 tests
Range 0.312-20 ng/mL
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