| Gene Symbol |
KDM1A
|
| Entrez Gene |
23028
|
| Alt Symbol |
AOF2, BHC110, KDM1, LSD1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysine (K)-specific demethylase 1A
|
| Other Description |
BRAF35-HDAC complex protein BHC110|FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit|amine oxidase (flavin containing) domain 2|flavin-containing amine oxidase domain-containing protein 2|lysine (K)-specific demethylase 1|lysine-specific histone demethylase 1|lysine-specific histone demethylase 1A
|
| Swissprots |
Q5TH94 Q5TH95 O60341 Q8IXK4 A8MWP9 Q86VT7 Q96AW4 Q8TAZ3 Q8NDP6
|
| Accessions |
CBY79414 CBY88366 EAW95031 EAW95032 EAW95033 O60341 AA664447 AB011173 BAA25527 AK128669 AK290328 BAF83017 AL833812 CAD38675 BC016639 AAH16639 BC025362 AAH25362 BC040194 AAH40194 BC048134 AAH48134 BG717076 BQ006926 XM_005245786 XP_005245843 XM_006710472 XP_006710535 XM_006710473 XP_006710536 XM_006710474 XP_006710537 NM_001009999 NP_001009999 NM_015013 NP_055828
|
| Function |
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specific tag tha
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11102443, ECO:0000269|PubMed:16079795}.
|
| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269|PubMed:16079795}.
|