| Gene Symbol |
SKA3
|
| Entrez Gene |
221150
|
| Alt Symbol |
C13orf3, RAMA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindle and kinetochore associated complex subunit 3
|
| Other Description |
spindle and kinetochore-associated protein 3
|
| Swissprots |
Q5VZV5 A2A331 A2A330 Q8IX90 Q8NBG1 B2RBY2 Q86WR2 Q96D22
|
| Accessions |
EAX08293 EAX08294 EAX08295 Q8IX90 AF361358 AAO13796 AK090584 BAC03484 AK307976 AK314864 BAG37379 BC013418 AAH13418 BC048988 AAH48988 BI460315 HQ447993 ADQ32474 XM_005266288 XP_005266345 XM_011534994 XP_011533296 NM_001166017 NP_001159489 NM_145061 NP_659498
|
| Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner.
|
![Western Blot: SKA3 Overexpression Lysate (Adult Normal) [NBP2-05508] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SKA3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10328_SKA3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05508-img0001.jpg)
![Western Blot: SKA3 Overexpression Lysate (Adult Normal) [NBP2-10145] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SKA3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/24008_SKA3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-10145-img0001.jpg)