Gene Symbol | SKA3 |
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Entrez Gene | 221150 |
Alt Symbol | C13orf3, RAMA1 |
Species | Human |
Gene Type | protein-coding |
Description | spindle and kinetochore associated complex subunit 3 |
Other Description | spindle and kinetochore-associated protein 3 |
Swissprots | Q5VZV5 A2A331 A2A330 Q8IX90 Q8NBG1 B2RBY2 Q86WR2 Q96D22 |
Accessions | EAX08293 EAX08294 EAX08295 Q8IX90 AF361358 AAO13796 AK090584 BAC03484 AK307976 AK314864 BAG37379 BC013418 AAH13418 BC048988 AAH48988 BI460315 HQ447993 ADQ32474 XM_005266288 XP_005266345 XM_011534994 XP_011533296 NM_001166017 NP_001159489 NM_145061 NP_659498 |
Function | Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002}. |
Subcellular Location | Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. |
Ska3 CRISPR/Cas9 KO Plasmid (h) - sc-405767 from Santa Cruz Biotechnology
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Ska3 HDR Plasmid (h) - sc-405767-HDR from Santa Cruz Biotechnology
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Ska3 Double Nickase Plasmid (h) - sc-405767-NIC from Santa Cruz Biotechnology
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Ska3 Double Nickase Plasmid (h2) - sc-405767-NIC-2 from Santa Cruz Biotechnology
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Ska3 CRISPR Activation Plasmid (h) - sc-405767-ACT from Santa Cruz Biotechnology
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Ska3 CRISPR Activation Plasmid (h2) - sc-405767-ACT-2 from Santa Cruz Biotechnology
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Ska3 Lentiviral Activation Particles (h) - sc-405767-LAC from Santa Cruz Biotechnology
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Ska3 Lentiviral Activation Particles (h2) - sc-405767-LAC-2 from Santa Cruz Biotechnology
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Ska3 siRNA (h) - sc-105145 from Santa Cruz Biotechnology
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Ska3 shRNA Plasmid (h) - sc-105145-SH from Santa Cruz Biotechnology
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Ska3 shRNA (h) Lentiviral Particles - sc-105145-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU088171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19375 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19375 from Sigma-Aldrich
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SKA3 siRNA (Human) - CRJ6493 from Cohesion Biosciences
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SKA3 - MBS8229078 from MyBioSource
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shRNA set against Human SKA3 (NM_145061.5) - SHH407928 from Creative biogene
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SKA3 shRNA Plasmid (Human) - CHJ6493 from Cohesion Biosciences
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SKA3 miRNA 3'UTR clone - MiUTR3H-13882 from Creative biogene
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SKA3 miRNA 3'UTR clone - MiUTR3H-13883 from Creative biogene
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