NUP153

Gene Symbol NUP153
Entrez Gene 9972
Alt Symbol HNUP153, N153
Species Human
Gene Type protein-coding
Description nucleoporin 153kDa
Other Description 153 kDa nucleoporin|nuclear pore complex protein Nup153|nuclear pore complex protein hnup153|nucleoporin 153kD|nucleoporin Nup153
Swissprots Q4LE47 Q5T9I7 P49790 F6QR24 E7EPX5 B4DIK2 Q7Z743
Accessions EAW55384 EAW55385 P49790 AB210024 BAE06106 AI948895 AK295644 BAG58514 AL597150 AW269393 BC052965 AAH52965 CB217525 DA856239 Z25535 CAA80982 XM_005249507 XP_005249564 XM_006715290 XP_006715353 XM_006715291 XP_006715354 XM_011515028 XP_011513330 NM_001278209 NP_001265138 NM_001278210 NP_001265139 NM_005124 NP_005115
Function Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.
Subcellular Location Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.
Top Pathways RNA transport

Human NUP153 cDNA clone(NM_005124.2) - CDFH012985 from Creative Biomart

Species Human
Accession NM_005124.2

Human NUP153 ORF Clone(NM_005124.2) - CDCR289649 from Creative Biomart

Species Human
Accession NM_005124.2

Human NUP153 ORF Clone(NM_005124.2) - CDCR289650 from Creative Biomart

Species Human
Accession NM_005124.2

Human NUP153 ORF clone (NM_005124.2) - CDCL140683 from Creative biogene

Species Human

Human NUP153 cDNA Clone(NM_005124.2) - CDFH012985 from Creative biogene

Species Human
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