NUP153

Gene Symbol	NUP153
Entrez Gene	9972
Alt Symbol	HNUP153, N153
Species	Human
Gene Type	protein-coding
Description	nucleoporin 153kDa
Other Description	153 kDa nucleoporin|nuclear pore complex protein Nup153|nuclear pore complex protein hnup153|nucleoporin 153kD|nucleoporin Nup153
Swissprots	Q4LE47 Q5T9I7 P49790 F6QR24 E7EPX5 B4DIK2 Q7Z743
Accessions	EAW55384 EAW55385 P49790 AB210024 BAE06106 AI948895 AK295644 BAG58514 AL597150 AW269393 BC052965 AAH52965 CB217525 DA856239 Z25535 CAA80982 XM_005249507 XP_005249564 XM_006715290 XP_006715353 XM_006715291 XP_006715354 XM_011515028 XP_011513330 NM_001278209 NP_001265138 NM_001278210 NP_001265139 NM_005124 NP_005115
Function	Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat- containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). {ECO:0000269|PubMed:12802065, ECO:0000269|PubMed:15229283, ECO:0000269|PubMed:22253824}.
Subcellular Location	Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina (By similarity). Localized to the nucleoplasmic side of the nuclear pore complex (NPC) core structure, forming a fibrous structure called the nuclear basket. Dissociates from the NPC structure early during prophase of mitosis. Integrated in the newly assembled nuclear envelope of postmitotic cells early in G1. Colocalized with NUP98 and TPR to the nuclear basket at the nucleoplasmic side of the NPC. Detected in diffuse and discrete intranuclear foci. Remained localized to the nuclear membrane after poliovirus (PV) infection. {ECO:0000250}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Nup153 CRISPR/Cas9 KO Plasmid (h) - sc-403206 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 HDR Plasmid (h) - sc-403206-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 Double Nickase Plasmid (h) - sc-403206-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 Double Nickase Plasmid (h2) - sc-403206-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 CRISPR Activation Plasmid (h) - sc-403206-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 CRISPR Activation Plasmid (h2) - sc-403206-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 Lentiviral Activation Particles (h) - sc-403206-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 Lentiviral Activation Particles (h2) - sc-403206-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 siRNA (h) - sc-41279 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nup153 shRNA Plasmid (h) - sc-41279-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nup153 shRNA (h) Lentiviral Particles - sc-41279-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Nup153 RNAi - H00009972-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU081411 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15619 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15619 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07632 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07632

NUP153 siRNA (Human) - CRH6709 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Nup153 CRISPR/Cas9 KO Plasmid (h2) - sc-403206-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Nup153 HDR Plasmid (h2) - sc-403206-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human Nup153 (NM_005124.2) - SHH356364 from Creative biogene Category siRNA Species Reactivities Human

Human NUP153 siRNA - orb267211 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

NUP153 siRNA - orb219196 from Biorbyt Category siRNA Prices $417.00 Sizes 5 od (260 nm) Species Reactivities Human

NUP153 shRNA Plasmid (Human) - CHH6709 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

NUP153 miRNA 3'UTR clone - MiUTR1H-06984 from Creative biogene Species Reactivities Human

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