Rgn

Gene Symbol	Rgn
Entrez Gene	19733
Alt Symbol	AI265316, GNL, SMP30
Species	Mouse
Gene Type	protein-coding
Description	regucalcin
Other Description	RC\|SMP-30\|gluconolactonase\|senescence marker protein 30
Swissprots	A2AFC8 Q64374 Q3UJG3 Q60944
Accessions	AAD03478 EDL00749 Q64374 AK146465 BAE27192 BC012710 AAH12710 D86217 BAA13046 U28937 AAC52721 XM_006527572 XP_006527635 NM_009060 NP_033086
Function	Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Mainly present in the liver. Weak expression was found in the brain, lung and kidney. {ECO:0000269\|PubMed:8765750, ECO:0000269\|PubMed:9278263}.
Top Pathways	Pentose phosphate pathway, Ascorbate and aldarate metabolism, Carbon metabolism, Degradation of aromatic compounds

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