| Gene Symbol |
Rgn
|
| Entrez Gene |
19733
|
| Alt Symbol |
AI265316, GNL, SMP30
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
regucalcin
|
| Other Description |
RC|SMP-30|gluconolactonase|senescence marker protein 30
|
| Swissprots |
A2AFC8 Q64374 Q3UJG3 Q60944
|
| Accessions |
AAD03478 EDL00749 Q64374 AK146465 BAE27192 BC012710 AAH12710 D86217 BAA13046 U28937 AAC52721 XM_006527572 XP_006527635 NM_009060 NP_033086
|
| Function |
Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Mainly present in the liver. Weak expression was found in the brain, lung and kidney. {ECO:0000269|PubMed:8765750, ECO:0000269|PubMed:9278263}.
|
| Top Pathways |
Pentose phosphate pathway, Ascorbate and aldarate metabolism, Carbon metabolism, Degradation of aromatic compounds
|