| Gene Symbol | Rgn |
|---|---|
| Entrez Gene | 19733 |
| Alt Symbol | AI265316, GNL, SMP30 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | regucalcin |
| Other Description | RC|SMP-30|gluconolactonase|senescence marker protein 30 |
| Swissprots | A2AFC8 Q64374 Q3UJG3 Q60944 |
| Accessions | AAD03478 EDL00749 Q64374 AK146465 BAE27192 BC012710 AAH12710 D86217 BAA13046 U28937 AAC52721 XM_006527572 XP_006527635 NM_009060 NP_033086 |
| Function | Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Catalyzes a key step in ascorbic acid (vitamin C) biosynthesis. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Mainly present in the liver. Weak expression was found in the brain, lung and kidney. {ECO:0000269|PubMed:8765750, ECO:0000269|PubMed:9278263}. |
| Top Pathways | Pentose phosphate pathway, Ascorbate and aldarate metabolism, Carbon metabolism, Degradation of aromatic compounds |