MYO1E
| Gene Symbol | MYO1E |
|---|---|
| Entrez Gene | 4643 |
| Alt Symbol | FSGS6, HuncM-IC, MYO1C |
| Species | Human |
| Gene Type | protein-coding |
| Description | myosin IE |
| Other Description | MYO1E variant protein|myosin-IC|unconventional myosin 1E|unconventional myosin-Ie |
| Swissprots | Q14778 Q12965 |
| Accessions | EAW77564 Q12965 AB290177 BAG06731 AK291688 BAF84377 AL707587 BC067835 BC098392 AAH98392 BQ054624 BX489024 CA429161 CB128582 L29139 AAA20902 U14391 AAA62667 NM_004998 NP_004989 |
| Function | Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. {ECO:0000269|PubMed:11940582, ECO:0000269|PubMed:17257598, ECO:0000269|PubMed:20860408}. |
| Subcellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Cell junction {ECO:0000250}. Note=Colocalizes with F-actin (By similarity). In cultured podocytes, it localizes close to and is associated with the cytoplasmic membrane, with enrichment at the lamellipodia tips. Colocalizes with cytoplasmic vesicles, including endocytic clathrin-coated vesicles. Colocalizes with dynamin at cytoplasmic vesicles. {ECO:0000250}. |
| Tissue Specificity | Expressed in the immune system. In the kidney, predominantly expressed in the glomerulus, including podocytes. {ECO:0000269|PubMed:21458045, ECO:0000269|PubMed:21756023}. |
Myosin Ie CRISPR/Cas9 KO Plasmid (h) - sc-404605 from Santa Cruz Biotechnology
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Myosin Ie HDR Plasmid (h) - sc-404605-HDR from Santa Cruz Biotechnology
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Myosin Ie Double Nickase Plasmid (h) - sc-404605-NIC from Santa Cruz Biotechnology
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Myosin Ie Double Nickase Plasmid (h2) - sc-404605-NIC-2 from Santa Cruz Biotechnology
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Myosin Ie CRISPR Activation Plasmid (h) - sc-404605-ACT from Santa Cruz Biotechnology
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Myosin Ie CRISPR Activation Plasmid (h2) - sc-404605-ACT-2 from Santa Cruz Biotechnology
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Myosin Ie Lentiviral Activation Particles (h) - sc-404605-LAC from Santa Cruz Biotechnology
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Myosin Ie Lentiviral Activation Particles (h2) - sc-404605-LAC-2 from Santa Cruz Biotechnology
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Myosin Ie siRNA (h) - sc-44613 from Santa Cruz Biotechnology
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Myosin Ie shRNA Plasmid (h) - sc-44613-SH from Santa Cruz Biotechnology
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Myosin Ie shRNA (h) Lentiviral Particles - sc-44613-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU017431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14856 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14856 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07813 from Sigma-Aldrich
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MYO1E siRNA (Human) - CRH3067 from Cohesion Biosciences
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Myosin 1E RNAi - H00004643-R01 from Novus Biologicals
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Human MYO1E siRNA - orb263569 from Biorbyt
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MYO1E shRNA Plasmid (Human) - CHH3067 from Cohesion Biosciences
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MYO1E miRNA 3'UTR clone - MiUTR3H-04142 from Creative biogene
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