| Gene Symbol |
HSD3B2
|
| Entrez Gene |
3284
|
| Alt Symbol |
HSD3B, HSDB, SDR11E2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
|
| Other Description |
3 beta-HSD type II|3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2|3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II|3-beta-HSD II|3-beta-HSD adrenal and gonadal type|3-beta-hydroxy-5-ene steroid dehydrogenase|3-beta-hydroxy-Delta(5)-steroid dehydrogenase|delta 5-delta 4-isomerase type II|progesterone reductase|short chain dehydrogenase/reductase family 11E, member 2
|
| Swissprots |
Q9UD08 Q6AI10 A2RRA5 Q53GD4 P26439 Q16010 Q99890 Q6LDB9
|
| Accessions |
AAA36014 AAC60599 AAC60600 AAD14930 AJF45348 EAW56700 EAW56701 EAW56702 P26439 AK222997 BAD96717 AK313413 BAG36207 AV705363 BC038419 AAH38419 BC131488 AAI31489 BP197992 CF596786 DQ891764 ABM82690 DQ894948 ABM85874 M67466 AAA36016 NM_000198 NP_000189 NM_001166120 NP_001159592
|
| Function |
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in adrenal gland, testis and ovary.
|
| Top Pathways |
Steroid hormone biosynthesis, Ovarian steroidogenesis
|
![Western Blot: Beta Hydroxysteroid Dehydrogenase Overexpression Lysate (Adult Normal) [NBL1-11733] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Beta Hydroxysteroid Dehydrogenase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3222_Beta%2520Hydroxysteroid%2520Dehydrogenase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11733-img0002.jpg)