SIGLEC7

Gene Symbol	SIGLEC7
Entrez Gene	27036
Alt Symbol	AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 7
Other Description	AIRM-1|QA79 membrane protein|adhesion inhibitory receptor molecule 1, siglec-7|sialic acid binding immunoglobulin-like lectin 7|sialic acid-binding Ig-like lectin 7
Swissprots	Q9Y286 Q9UJ87 Q9NZQ1 Q9UJ86 Q9Y502
Accessions	AAK83656 EAW71986 EAW71987 Q9Y286 AF170485 AAF12759 AF178981 AAF44346 AF193441 AAF06790 AJ007395 CAB46011 AJ130710 CAB51126 AJ130711 CAB51127 AJ130712 CAB51128 AJ130713 CAB51129 AK314875 BAG37390 BC028150 AAH28150 BX644517 XM_006723140 XP_006723203 XM_011526721 XP_011525023 NM_001277201 NP_001264130 NM_014385 NP_055200 NM_016543 NP_057627 NR_102350
Function	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Siglec-7 (F-2) - sc-398181 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Siglec-7 (C-15) - sc-34931 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Siglec-7 (D-20) - sc-34932 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Siglec-7 (H-2) - sc-398166 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Siglec-7 (H-48) - sc-292452 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Siglec-7/12 (L-17) - sc-34933 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-Siglec 7 antibody - ab38573 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Siglec 7 antibody - ab38574 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Siglec 7 antibody - ab111619 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-Siglec 7 antibody - ab133388 from Abcam Prices $407.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Siglec 7 antibody - ab172457 from Abcam Prices $370.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-Siglec 7 antibody [6-434], prediluted (Phycoerythrin) - ab200558 from Abcam Prices $359.00 Sizes 100 tests Host Mouse Clonality Monoclonal Clone 6-434

Anti-Siglec 7 antibody [MM0551-8D8] - ab89483 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0551-8D8

Anti-Siglec 7 antibody - C-terminal - ab199184 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SIGLEC7 / CD328 Antibody (clone 5-386) - LS-C58033 from LifeSpan Bioscience Prices $275.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5-386

Anti-SIGLEC7 / CD328 Antibody (clone 5-386, FITC) - LS-C58113 from LifeSpan Bioscience Prices $330.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5-386

Anti-SIGLEC7 / CD328 Antibody - LS-C75831 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SIGLEC7 / CD328 Antibody - LS-C124545 from LifeSpan Bioscience Prices $485.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-SIGLEC7 / CD328 Antibody (PE) - LS-C132108 from LifeSpan Bioscience Prices $455.00 Sizes 100 tst Host Mouse Clonality Monoclonal

Anti-SIGLEC7 / CD328 Antibody (clone S7.7) - LS-C187563 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S7.7

Anti-SIGLEC7 / CD328 Antibody (N-Terminus, AP) - LS-C245827 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIGLEC7 / CD328 Antibody (clone 5-386, RPE) - LS-C58034 from LifeSpan Bioscience Prices $345.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 5-386

Anti-SIGLEC7 / CD328 Antibody (N-Terminus, APC) - LS-C245828 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SIGLEC7 / CD328 Antibody (aa19-357) - LS-C150069 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-SIGLEC7 / CD328 Antibody (N-Terminus, Biotin) - LS-C245829 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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