SIGLEC7

Gene Symbol	SIGLEC7
Entrez Gene	27036
Alt Symbol	AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 7
Other Description	AIRM-1|QA79 membrane protein|adhesion inhibitory receptor molecule 1, siglec-7|sialic acid binding immunoglobulin-like lectin 7|sialic acid-binding Ig-like lectin 7
Swissprots	Q9Y286 Q9UJ87 Q9NZQ1 Q9UJ86 Q9Y502
Accessions	AAK83656 EAW71986 EAW71987 Q9Y286 AF170485 AAF12759 AF178981 AAF44346 AF193441 AAF06790 AJ007395 CAB46011 AJ130710 CAB51126 AJ130711 CAB51127 AJ130712 CAB51128 AJ130713 CAB51129 AK314875 BAG37390 BC028150 AAH28150 BX644517 XM_006723140 XP_006723203 XM_011526721 XP_011525023 NM_001277201 NP_001264130 NM_014385 NP_055200 NM_016543 NP_057627 NR_102350
Function	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Siglec-7/CD328 DuoSet ELISA - DY1138 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 125.00 - 8,000 pg/mL

Custom Human Siglec-7 ELISA - ELH-Siglec7 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS2025193 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.058ng/mL. Range 0.156-10ng/mL

sialic acid binding Ig-like lectin 7, ELISA Kit - MBS9330506 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/ml. Range 0.25 ng/ml - 8 ng/ml.

ELISA Kit for Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) - SEB789Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7) - SEB789Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human SIGLEC7 / CD328 ELISA Kit (Sandwich ELISA) - LS-F25318 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Human Siglec-7 ELISA kit - orb196725 from Biorbyt Category ELISA Kit Prices $1,148.00, $1,981.00, $4,284.00 Sizes 96 assays, 192 assays, 480 assays

Human Siglec-7 ELISA - RAB1697 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Sialic acid-binding Ig-like lectin 7 ELISA Kit - EKE55396 from Biomatik Category ELISA Kit Prices $809.60, $3,440.80, $6,476.80 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/ml

SIGLEC7 ELISA Kit (Human) (OKEH02520) - OKEH02520 from Aviva Systems Biology Category ELISA Kit Prices $480.00 Sizes 96 wells Sensitivity < 0.056 ng/mL Range 0.156 - 10 ng/mL

Human Siglec-7/CD328 ELISA Kit - NR-E10379 from Novatein Biosciences Category ELISA Kit Prices $359.00 Sizes 96 t Range 125 -8000pg/ml

Human Siglec-7/CD328 PicoKine™ ELISA Kit EK1508 - EK1508 from Boster Bio Category ELISA Kit Prices $369.00 Sizes 1 kit Sensitivity <10pg/ml Range 125pg/ml-8000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Human CD328 ELISA Kit - CEK1895 from Cohesion Biosciences Category ELISA Kit Prices $360.00 Sizes 96 t Sensitivity 10 pg/ml Range 125 pg/ml - 8000 pg/ml

Custom Human Siglec-7 ELISA - ELH-Siglec7-1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human SIGLEC7 ELISA Kit - orb385343 from Biorbyt Category ELISA Kit Prices $731.00 Sizes 96 test Sensitivity 10 pg/ml Range 125 pg/ml-8000 pg/ml

Human SIGLEC7 ELISA Kit - E035173 from Biobool Category ELISA Kit Sensitivity Typically less than 0.058ng/mL.

Human Sialic acid-binding Ig-like lectin 7 ELISA Kit - EK3683 from Signalway Antibody Category ELISA Kit Prices $739.00 Sizes 1x96t Range 0.156-10 ng/ml

anti-CD328 / SIGLEC7 antibody [6-434] - ARG65401 from Arigo Biolaboratories Category ELISA Kit

Human Sialic acid-binding Ig-like lectin 7 (SIGLEC7) ELISA Kit - AE19527HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.058 ng/mL Range 0.156-10 ng/mL

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS9345962 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS9348332 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS9355586 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS9349980 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sialic Acid Binding Ig Like Lectin 7 (SIGLEC7), ELISA Kit - MBS9353556 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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