| Gene Symbol |
SIGLEC7
|
| Entrez Gene |
27036
|
| Alt Symbol |
AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sialic acid binding Ig-like lectin 7
|
| Other Description |
AIRM-1|QA79 membrane protein|adhesion inhibitory receptor molecule 1, siglec-7|sialic acid binding immunoglobulin-like lectin 7|sialic acid-binding Ig-like lectin 7
|
| Swissprots |
Q9Y286 Q9UJ87 Q9NZQ1 Q9UJ86 Q9Y502
|
| Accessions |
AAK83656 EAW71986 EAW71987 Q9Y286 AF170485 AAF12759 AF178981 AAF44346 AF193441 AAF06790 AJ007395 CAB46011 AJ130710 CAB51126 AJ130711 CAB51127 AJ130712 CAB51128 AJ130713 CAB51129 AK314875 BAG37390 BC028150 AAH28150 BX644517 XM_006723140 XP_006723203 XM_011526721 XP_011525023 NM_001277201 NP_001264130 NM_014385 NP_055200 NM_016543 NP_057627 NR_102350
|
| Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.
|