SIGLEC7

Gene Symbol	SIGLEC7
Entrez Gene	27036
Alt Symbol	AIRM1, CD328, CDw328, D-siglec, QA79, SIGLEC-7, SIGLEC19P, SIGLECP2, p75, p75/AIRM1
Species	Human
Gene Type	protein-coding
Description	sialic acid binding Ig-like lectin 7
Other Description	AIRM-1|QA79 membrane protein|adhesion inhibitory receptor molecule 1, siglec-7|sialic acid binding immunoglobulin-like lectin 7|sialic acid-binding Ig-like lectin 7
Swissprots	Q9Y286 Q9UJ87 Q9NZQ1 Q9UJ86 Q9Y502
Accessions	AAK83656 EAW71986 EAW71987 Q9Y286 AF170485 AAF12759 AF178981 AAF44346 AF193441 AAF06790 AJ007395 CAB46011 AJ130710 CAB51126 AJ130711 CAB51127 AJ130712 CAB51128 AJ130713 CAB51129 AK314875 BAG37390 BC028150 AAH28150 BX644517 XM_006723140 XP_006723203 XM_011526721 XP_011525023 NM_001277201 NP_001264130 NM_014385 NP_055200 NM_016543 NP_057627 NR_102350
Function	Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). {ECO:0000269|PubMed:10611343}.
Subcellular Location	Membrane; Single-pass type I membrane protein.
Tissue Specificity	Predominantly expressed by resting and activated natural killer cells and at lower levels by granulocytes and monocytes. High expression found in placenta, liver, lung, spleen, and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Siglec 7 full length protein - ab162060 from Abcam Category Protein Source Wheat germ Species Human

Human Siglec 7 protein fragment - ab162061 from Abcam Category Protein Source Wheat germ Species Human

SIGLEC7 / CD328 Antibody Blocking Peptide - LS-E4035 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIGLEC7 / CD328 Antibody Blocking Peptide - LS-E4099 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIGLEC7 / CD328 Antibody Blocking Peptide - LS-E4100 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIGLEC7 / CD328 Antibody Blocking Peptide - LS-E17075 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SIGLEC7 / CD328 Antibody Blocking Peptide - LS-E17074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Siglec-7/CD328 Recombinant Protein - H00027036-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human Siglec-7/CD328 Protein - H00027036-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Siglec-7/CD328 Protein - H00027036-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

Siglec-7/CD328 Peptide - P0611 from Novus Biologicals Category Peptide Species Human

Siglec-7/CD328 Peptide - P0599 from Novus Biologicals Category Peptide Species Human

SIGLEC7-D-siglec-Antibody-N-term-Blocking-peptide - BP1625a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIGLEC7-D-siglec-Antibody-C-term-H422-Blocking-peptide - BP1633c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SIGLEC7-D-siglec-Antibody-N-term-Blocking-peptide - BP1633a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Siglec-7/CD328 Fc Chimera, CF - 1138-SL-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

SIGLEC7 Protein Lysate (APL10507) - APL10507 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SIGLEC7 Protein Lysate (APL10508) - APL10508 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SIGLEC7 Blocking Peptide - 33R-10031 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SIGLEC7 Blocking Peptide - 33R-10007 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human SIGLEC7 Protein - abx069072 from Abbexa Category Protein Source E.coli Species Human

Human SIGLEC7 Protein - abx069073 from Abbexa Category Protein Source E.coli Species Human

Human SIGLEC7 Protein - abx069071 from Abbexa Category Protein Source E.coli Species Human

CD328 / SIGLEC7 - H00027036-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD328 / SIGLEC7 - H00027036-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

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