| Gene Symbol |
APOBEC3H
|
| Entrez Gene |
164668
|
| Alt Symbol |
A3H, ARP-10, ARP10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
|
| Other Description |
APOBEC-related protein 10|DNA dC->dU-editing enzyme APOBEC-3H
|
| Swissprots |
Q5JYL9 E9PF38 B7TQM5 B0QYP1 Q6NTF7 Q6IC87 B0QYP0
|
| Accessions |
ACJ60861 EAW60294 EAW60295 EAW60296 Q6NTF7 BC069023 AAH69023 BQ052182 BQ054330 BU585251 CR456481 CAG30367 FJ376611 ACK77772 FJ376612 ACK77773 FJ376613 ACK77774 FJ376614 ACK77775 FJ376615 ACK77776 FJ376616 ACK77777 FJ376617 ACK77778 KC329529 AGI04217 XM_011529990 XP_011528292 XM_011529991 XP_011528293 XM_011529992 XP_011528294 NM_001166002 NP_001159474 NM_001166003 NP_001159475 NM_001166004 NP_001159476 NM_181773 NP_861438
|
| Function |
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H- var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit th
|
| Subcellular Location |
Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
|
| Tissue Specificity |
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin. {ECO:0000269|PubMed:16571802, ECO:0000269|PubMed:20308164}.
|