APOBEC3H

Gene Symbol APOBEC3H
Entrez Gene 164668
Alt Symbol A3H, ARP-10, ARP10
Species Human
Gene Type protein-coding
Description apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Other Description APOBEC-related protein 10|DNA dC->dU-editing enzyme APOBEC-3H
Swissprots Q5JYL9 E9PF38 B7TQM5 B0QYP1 Q6NTF7 Q6IC87 B0QYP0
Accessions ACJ60861 EAW60294 EAW60295 EAW60296 Q6NTF7 BC069023 AAH69023 BQ052182 BQ054330 BU585251 CR456481 CAG30367 FJ376611 ACK77772 FJ376612 ACK77773 FJ376613 ACK77774 FJ376614 ACK77775 FJ376615 ACK77776 FJ376616 ACK77777 FJ376617 ACK77778 KC329529 AGI04217 XM_011529990 XP_011528292 XM_011529991 XP_011528293 XM_011529992 XP_011528294 NM_001166002 NP_001159474 NM_001166003 NP_001159475 NM_001166004 NP_001159476 NM_181773 NP_861438
Function DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H- var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single- stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit th
Subcellular Location Nucleus. Cytoplasm. Cytoplasm, P-body. Note=Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
Tissue Specificity Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin. {ECO:0000269|PubMed:16571802, ECO:0000269|PubMed:20308164}.

APOBEC3H CRISPR/Cas9 KO Plasmid (h) - sc-409386 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H HDR Plasmid (h) - sc-409386-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H Double Nickase Plasmid (h) - sc-409386-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H Double Nickase Plasmid (h2) - sc-409386-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H CRISPR Activation Plasmid (h) - sc-409386-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H CRISPR Activation Plasmid (h2) - sc-409386-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H Lentiviral Activation Particles (h) - sc-409386-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H Lentiviral Activation Particles (h2) - sc-409386-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

APOBEC3H siRNA (h) - sc-72517 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APOBEC3H shRNA Plasmid (h) - sc-72517-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

APOBEC3H shRNA (h) Lentiviral Particles - sc-72517-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU067761 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3340 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3340 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

APOBEC3H siRNA (Human) - CRJ6017 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ARP10 RNAi - H00164668-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

APOBEC3H - MBS8223330 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Apobec3 (NM_181773.3) - SHH238418 from Creative biogene

Category siRNA
Species Reactivities Human

APOBEC3H shRNA Plasmid (Human) - CHJ6017 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

APOBEC3H miRNA 3'UTR clone - MiUTR4H-TG00420 from Creative biogene

Species Reactivities Human
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