REL
| Gene Symbol | REL |
|---|---|
| Entrez Gene | 5966 |
| Alt Symbol | C-Rel |
| Species | Human |
| Gene Type | protein-coding |
| Description | v-rel avian reticuloendotheliosis viral oncogene homolog |
| Other Description | oncogene REL, avian reticuloendotheliosis|proto-oncogene c-Rel |
| Swissprots | Q17RU2 Q04864 Q6LDY0 Q2PNZ7 |
| Accessions | AAA52073 ABC40747 CBX47437 EAX00028 Q04864 AA279919 AK123369 AK303926 BAG64854 BC051005 BC117191 AAI17192 BC143885 AAI43886 BG036646 BX111941 CN414487 HY123671 X75042 CAA52954 XM_011533010 XP_011531312 NM_001291746 NP_001278675 NM_002908 NP_002899 |
| Function | Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an in |
| Subcellular Location | Nucleus {ECO:0000250}. |
| Top Pathways | Viral carcinogenesis, Transcriptional misregulation in cancer |
c-Rel CRISPR/Cas9 KO Plasmid (h) - sc-400478 from Santa Cruz Biotechnology
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c-Rel HDR Plasmid (h) - sc-400478-HDR from Santa Cruz Biotechnology
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c-Rel Double Nickase Plasmid (h) - sc-400478-NIC from Santa Cruz Biotechnology
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c-Rel Double Nickase Plasmid (h2) - sc-400478-NIC-2 from Santa Cruz Biotechnology
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c-Rel CRISPR Activation Plasmid (h) - sc-400478-ACT from Santa Cruz Biotechnology
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c-Rel CRISPR Activation Plasmid (h2) - sc-400478-ACT-2 from Santa Cruz Biotechnology
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c-Rel Lentiviral Activation Particles (h) - sc-400478-LAC from Santa Cruz Biotechnology
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c-Rel Lentiviral Activation Particles (h2) - sc-400478-LAC-2 from Santa Cruz Biotechnology
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c-Rel siRNA (h) - sc-29857 from Santa Cruz Biotechnology
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c-Rel shRNA Plasmid (h) - sc-29857-SH from Santa Cruz Biotechnology
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c-Rel shRNA (h) Lentiviral Particles - sc-29857-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU001951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18135 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18135 from Sigma-Aldrich
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REL siRNA (Human) - CRH4037 from Cohesion Biosciences
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c-Rel RNAi - H00005966-R01 from Novus Biologicals
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REL - MBS8200439 from MyBioSource
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shRNA set against Human Rel (NM_002908.2) - SHH391788 from Creative biogene
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REL shRNA Plasmid (Human) - CHH4037 from Cohesion Biosciences
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REL miRNA 3'UTR clone - MiUTR1H-08730 from Creative biogene
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