| Gene Symbol | RAB1A |
|---|---|
| Entrez Gene | 5861 |
| Alt Symbol | RAB1, YPT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB1A, member RAS oncogene family |
| Other Description | GTP binding protein Rab1a|RAB1, member RAS oncogene family|Rab GTPase YPT1 homolog|YPT1-related protein|ras-related protein Rab-1A |
| Swissprots | P62820 Q6FIE7 |
| Accessions | AAK94463 EAW99917 EAW99918 EAW99919 EAW99920 EAW99921 EAW99922 EAW99923 EAW99924 EAW99925 P62820 AF498929 AAM21077 AI768809 AK055927 BAB71048 AK303678 BAH14013 AK315495 BAG37879 AL050268 CAB43369 AM392684 CAL37562 BC000905 AAH00905 BG704216 BT019528 AAV38335 BT019529 AAV38336 BX571747 CAE11872 CR533479 CAG38510 CR536488 CAG38727 DC352417 DQ894084 ABM85010 EU831590 ACE87190 EU831675 ACE86509 M28209 AAA60240 X13898 CAA32098 XM_005264468 XP_005264525 XM_011533009 XP_011531311 NM_004161 NP_004152 NM_015543 NP_056358 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. {ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|P |
| Subcellular Location | Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome {ECO:0000250}. Note=Alternates between membrane-associated and cytosolic forms. |
| Top Pathways | Legionellosis |
Rab 1A CRISPR/Cas9 KO Plasmid (h) - sc-401515 from Santa Cruz Biotechnology
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Rab 1A HDR Plasmid (h) - sc-401515-HDR from Santa Cruz Biotechnology
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Rab 1A Double Nickase Plasmid (h) - sc-401515-NIC from Santa Cruz Biotechnology
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Rab 1A Double Nickase Plasmid (h2) - sc-401515-NIC-2 from Santa Cruz Biotechnology
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Rab 1A CRISPR Activation Plasmid (h) - sc-401515-ACT from Santa Cruz Biotechnology
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Rab 1A CRISPR Activation Plasmid (h2) - sc-401515-ACT-2 from Santa Cruz Biotechnology
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Rab 1A Lentiviral Activation Particles (h) - sc-401515-LAC from Santa Cruz Biotechnology
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Rab 1A Lentiviral Activation Particles (h2) - sc-401515-LAC-2 from Santa Cruz Biotechnology
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Rab 1A siRNA (h) - sc-41808 from Santa Cruz Biotechnology
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Rab 1A shRNA Plasmid (h) - sc-41808-SH from Santa Cruz Biotechnology
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Rab 1A shRNA (h) Lentiviral Particles - sc-41808-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU088831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17816 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17816 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09893 from Sigma-Aldrich
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RAB1A siRNA (Human) - CRH3951 from Cohesion Biosciences
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RAB1A - MBS8235545 from MyBioSource
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shRNA set against Human RAB1A (NM_004161.4) - SHH387984 from Creative biogene
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Human RAB1A siRNA - orb264453 from Biorbyt
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RAB1A shRNA Plasmid (Human) - CHH3951 from Cohesion Biosciences
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RAB1A miRNA 3'UTR clone - MiUTR3H-01981 from Creative biogene
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RAB1A miRNA 3'UTR clone - MiUTR3H-01982 from Creative biogene
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