RAB1A
| Gene Symbol | RAB1A |
|---|---|
| Entrez Gene | 5861 |
| Alt Symbol | RAB1, YPT1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | RAB1A, member RAS oncogene family |
| Other Description | GTP binding protein Rab1a|RAB1, member RAS oncogene family|Rab GTPase YPT1 homolog|YPT1-related protein|ras-related protein Rab-1A |
| Swissprots | P62820 Q6FIE7 |
| Accessions | AAK94463 EAW99917 EAW99918 EAW99919 EAW99920 EAW99921 EAW99922 EAW99923 EAW99924 EAW99925 P62820 AF498929 AAM21077 AI768809 AK055927 BAB71048 AK303678 BAH14013 AK315495 BAG37879 AL050268 CAB43369 AM392684 CAL37562 BC000905 AAH00905 BG704216 BT019528 AAV38335 BT019529 AAV38336 BX571747 CAE11872 CR533479 CAG38510 CR536488 CAG38727 DC352417 DQ894084 ABM85010 EU831590 ACE87190 EU831675 ACE86509 M28209 AAA60240 X13898 CAA32098 XM_005264468 XP_005264525 XM_011533009 XP_011531311 NM_004161 NP_004152 NM_015543 NP_056358 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. {ECO:0000269|PubMed:20639577, ECO:0000269|PubMed:20861236, ECO:0000269|P |
| Subcellular Location | Golgi apparatus. Endoplasmic reticulum. Early endosome. Cytoplasm, cytosol. Membrane. Melanosome {ECO:0000250}. Note=Alternates between membrane-associated and cytosolic forms. |
| Top Pathways | Legionellosis |
Active mouse Rab1A full length protein - ab90795 from Abcam
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Human Rab1A full length protein - ab152644 from Abcam
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Human Rab1A full length protein - ab152645 from Abcam
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RAB1A Antibody Blocking Peptide - LS-E20554 from LifeSpan Bioscience
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Rab1A Recombinant Protein - H00005861-P02 from Novus Biologicals
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Rab1A Recombinant Protein - H00005861-P01 from Novus Biologicals
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Rab1A Partial Recombinant Protein - H00005861-Q01 from Novus Biologicals
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Recombinant Human Rab1A Protein - NBP1-50980 from Novus Biologicals
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Rab1A Protein - NBP2-33367 from Novus Biologicals
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RAB1A Protein (OPPA00060) - OPPA00060 from Aviva Systems Biology
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Human RAB1A protein - orb169134 from Biorbyt
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Human RAB1 protein - orb245026 from Biorbyt
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RAB1A Blocking Peptide - 33R-1303 from Fitzgerald
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RAB1A / RAB1 (1-205, His-tag) - AR09840PU-L from Acris Antibodies
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RAB1A / RAB1 (1-205, His-tag) - AR09840PU-N from Acris Antibodies
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RAB1A / RAB1 - H00005861-P01-10 from Acris Antibodies
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RAB1A / RAB1 - H00005861-P01-25 from Acris Antibodies
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RAB1A / RAB1 - H00005861-P02 from Acris Antibodies
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RAB1A / RAB1 - H00005861-P02-10 from Acris Antibodies
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RAB1A / RAB1 - H00005861-P02-25 from Acris Antibodies
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RAB1A / RAB1 - H00005861-Q01-10 from Acris Antibodies
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RAB1A / RAB1 - H00005861-Q01-25 from Acris Antibodies
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RAB1A, Member RAS Oncogene Family Recombinant Human - 228-12817-1 from RayBiotech
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Recombinant RAB1A, Member RAS Oncogene Family Human - 228-12817-2 from RayBiotech
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Recombinant RAB1A, Member RAS Oncogene Family Human - 228-12817-3 from RayBiotech
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