| Gene Symbol |
SSTR5
|
| Entrez Gene |
6755
|
| Alt Symbol |
SS-5-R
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
somatostatin receptor 5
|
| Other Description |
somatostatin receptor subtype 5|somatostatin receptor type 5
|
| Swissprots |
P35346 Q9UJI5 P34988 Q541E0
|
| Accessions |
AAA20828 AAB31829 AAD38178 AAK61266 AAL88744 AAN86611 BAA04107 CBE74695 CDM63488 EAW85687 P35346 AK308381 BC141553 AAI41554 BC146576 AAI46577 DB202230 DQ448303 ABE27002 DQ448304 ABE27003 DW447547 XM_006720936 XP_006720999 NM_001053 NP_001044 NM_001172560 NP_001166031 NM_001172572 NM_001172573
|
| Function |
Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491}.
|
| Top Pathways |
cAMP signaling pathway, Neuroactive ligand-receptor interaction
|