Gene Symbol | SSTR5 |
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Entrez Gene | 6755 |
Alt Symbol | SS-5-R |
Species | Human |
Gene Type | protein-coding |
Description | somatostatin receptor 5 |
Other Description | somatostatin receptor subtype 5|somatostatin receptor type 5 |
Swissprots | P35346 Q9UJI5 P34988 Q541E0 |
Accessions | AAA20828 AAB31829 AAD38178 AAK61266 AAL88744 AAN86611 BAA04107 CBE74695 CDM63488 EAW85687 P35346 AK308381 BC141553 AAI41554 BC146576 AAI46577 DB202230 DQ448303 ABE27002 DQ448304 ABE27003 DW447547 XM_006720936 XP_006720999 NM_001053 NP_001044 NM_001172560 NP_001166031 NM_001172572 NM_001172573 |
Function | Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491, ECO:0000269|PubMed:8373420}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus. No expression in fetal or adult kidney, liver, pancreas, uterus, spleen, lung, thyroid or ovary. {ECO:0000269|PubMed:12072395, ECO:0000269|PubMed:7908405, ECO:0000269|PubMed:8078491}. |
Top Pathways | cAMP signaling pathway, Neuroactive ligand-receptor interaction |
SSTR5 CRISPR/Cas9 KO Plasmid (h) - sc-404199 from Santa Cruz Biotechnology
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SSTR5 HDR Plasmid (h) - sc-404199-HDR from Santa Cruz Biotechnology
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SSTR5 Double Nickase Plasmid (h) - sc-404199-NIC from Santa Cruz Biotechnology
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SSTR5 Double Nickase Plasmid (h2) - sc-404199-NIC-2 from Santa Cruz Biotechnology
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SSTR5 CRISPR Activation Plasmid (h) - sc-404199-ACT from Santa Cruz Biotechnology
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SSTR5 CRISPR Activation Plasmid (h2) - sc-404199-ACT-2 from Santa Cruz Biotechnology
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SSTR5 Lentiviral Activation Particles (h) - sc-404199-LAC from Santa Cruz Biotechnology
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SSTR5 Lentiviral Activation Particles (h2) - sc-404199-LAC-2 from Santa Cruz Biotechnology
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SSTR5 siRNA (h) - sc-42277 from Santa Cruz Biotechnology
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SSTR5 shRNA Plasmid (h) - sc-42277-SH from Santa Cruz Biotechnology
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SSTR5 shRNA (h) Lentiviral Particles - sc-42277-V from Santa Cruz Biotechnology
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Somatostatin R5/SSTR5 RNAi - H00006755-R02 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN1950 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1950 from Sigma-Aldrich
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SSTR5 siRNA (Human) - CRH4618 from Cohesion Biosciences
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SSTR5 - MBS8212265 from MyBioSource
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SSTR5 CRISPR/Cas9 KO Plasmid (h2) - sc-404199-KO-2 from Santa Cruz Biotechnology
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SSTR5 HDR Plasmid (h2) - sc-404199-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human SSTR5 (NM_001053.3) - SHH418616 from Creative biogene
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SSTR5 shRNA Plasmid (Human) - CHH4618 from Cohesion Biosciences
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