| Gene Symbol |
RPAP2
|
| Entrez Gene |
79871
|
| Alt Symbol |
C1orf82, Rtr1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA polymerase II associated protein 2
|
| Other Description |
RNA polymerase II-associated protein 2|putative RNA polymerase II subunit B1 CTD phosphatase RPAP2
|
| Swissprots |
Q8IXW5 Q49AS7 C9JKB5 Q9H8Y2
|
| Accessions |
EAW73095 EAW73096 Q8IXW5 AI612918 AK023212 BAB14465 AK225054 BC031070 AAH31070 BC039014 AAH39014 JF432356 ADZ15573 XM_005271223 XP_005271280 XM_006710905 XP_006710968 XM_011542167 XP_011540469 XM_011542168 XP_011540470 XR_246295 NM_024813 NP_079089
|
| Function |
Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22137580}. Nucleus {ECO:0000269|PubMed:22137580}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner.
|
![Western Blot: RPAP2 Overexpression Lysate (Adult Normal) [NBL1-15493] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RPAP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11299_RPAP2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-15493-img0002.jpg)