Gene Symbol | RPAP2 |
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Entrez Gene | 79871 |
Alt Symbol | C1orf82, Rtr1 |
Species | Human |
Gene Type | protein-coding |
Description | RNA polymerase II associated protein 2 |
Other Description | RNA polymerase II-associated protein 2|putative RNA polymerase II subunit B1 CTD phosphatase RPAP2 |
Swissprots | Q8IXW5 Q49AS7 C9JKB5 Q9H8Y2 |
Accessions | EAW73095 EAW73096 Q8IXW5 AI612918 AK023212 BAB14465 AK225054 BC031070 AAH31070 BC039014 AAH39014 JF432356 ADZ15573 XM_005271223 XP_005271280 XM_006710905 XP_006710968 XM_011542167 XP_011540469 XM_011542168 XP_011540470 XR_246295 NM_024813 NP_079089 |
Function | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:22137580}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:22137580}. Nucleus {ECO:0000269|PubMed:22137580}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. |
RPAP2 CRISPR/Cas9 KO Plasmid (h) - sc-413279 from Santa Cruz Biotechnology
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RPAP2 HDR Plasmid (h) - sc-413279-HDR from Santa Cruz Biotechnology
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RPAP2 Double Nickase Plasmid (h) - sc-413279-NIC from Santa Cruz Biotechnology
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RPAP2 Double Nickase Plasmid (h2) - sc-413279-NIC-2 from Santa Cruz Biotechnology
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RPAP2 CRISPR Activation Plasmid (h) - sc-413279-ACT from Santa Cruz Biotechnology
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RPAP2 CRISPR Activation Plasmid (h2) - sc-413279-ACT-2 from Santa Cruz Biotechnology
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RPAP2 Lentiviral Activation Particles (h) - sc-413279-LAC from Santa Cruz Biotechnology
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RPAP2 Lentiviral Activation Particles (h2) - sc-413279-LAC-2 from Santa Cruz Biotechnology
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RPAP2 siRNA (h) - sc-78826 from Santa Cruz Biotechnology
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RPAP2 shRNA Plasmid (h) - sc-78826-SH from Santa Cruz Biotechnology
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RPAP2 shRNA (h) Lentiviral Particles - sc-78826-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU002371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18521 from Sigma-Aldrich
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RPAP2 siRNA (Human) - CRJ2629 from Cohesion Biosciences
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RPAP2 - MBS8214861 from MyBioSource
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shRNA set against Human RPAP2 (NM_024813.2) - SHH397912 from Creative biogene
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Human RPAP2 siRNA - orb273130 from Biorbyt
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RPAP2 shRNA Plasmid (Human) - CHJ2629 from Cohesion Biosciences
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RPAP2 miRNA 3'UTR clone - MiUTR3H-11917 from Creative biogene
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