| Gene Symbol |
HINFP
|
| Entrez Gene |
25988
|
| Alt Symbol |
HiNF-P, MIZF, ZNF743
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone H4 transcription factor
|
| Other Description |
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein|MBD2-interacting zinc finger 1|MBD2-interacting zinc finger protein|histone H4 gene-specific protein HiNF-P|histone nuclear factor P|methyl-CpG-binding protein 2-interacting zinc finger protein
|
| Swissprots |
E9PQF4 Q9BQA5 B4DWB4 Q96E65 Q9Y4M7 B3KPH6
|
| Accessions |
EAW67460 EAW67461 EAW67462 EAW67463 Q9BQA5 AK056362 BAG51688 AK092869 AK300288 BAG62045 AK301452 BAG62976 AL080201 CAB45773 BC001073 AAH01073 BC001945 AAH01945 BC012856 AAH12856 BC017234 AAH17234 BF726036 BG821695 DC326345 DQ894647 ABM85573 XM_006718814 XP_006718877 XM_011542744 XP_011541046 XM_011542745 XP_011541047 XM_011542746 XP_011541048 NM_001243259 NP_001230188 NM_015517 NP_056332 NM_198971 NP_945322
|
| Function |
Transcriptional repressor that binds to the consensus sequence 5'-CGGACGTT-3' and to the RB1 promoter. Transcriptional activator that promotes histone H4 gene transcription at the G1/S phase transition in conjunction with NPAT. Also activates transcription of the ATM and PRKDC genes. Autoregulates its expression by associating with its own promoter. {ECO:0000269|PubMed:11553631, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14752047, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:18850719}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11553631, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:18850719}. Note=Associated with discrete nuclear foci.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in brain, heart, skeletal muscle, spleen, kidney, small intestine, placenta and liver. {ECO:0000269|PubMed:11553631}.
|