Nanog

Gene Symbol	Nanog
Entrez Gene	71950
Alt Symbol	2410002E02Rik, ENK, ecat4
Species	Mouse
Gene Type	protein-coding
Description	Nanog homeobox
Other Description	ES cell-associated protein 4|early embryo specific expression NK family|early embryo specific expression NK-type homeobox protein|homeobox protein NANOG|homeobox transcription factor Nanog
Swissprots	Q7TN85 Q80Z64 Q6SMR1 Q5TM83
Accessions	ABD16123 ABD16124 CAH25963 EDK99694 Q5TM83 Q80Z64 AB093574 BAC76998 AB126939 BAD72892 AF507043 AAO67362 AK010332 BAE43219 AK167259 AY278951 AAP92157 AY455282 AAS57554 AY455285 AAS57556 BC083105 BC132017 AAI32018 BC137873 AAI37874 BC144995 AAI44996 BC144996 AAI44997 BY382803 XM_006506651 XP_006506714 XM_011241471 XP_011239773 XM_011241472 XP_011239774 XM_011241473 XP_011239775 NM_001289828 NP_001276757 NM_001289830 NP_001276759 NM_001289831 NP_001276760 NM_028016 NP_082292
Function	Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Top Pathways	Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics

Homeobox protein NANOG, Nanog, Mouse, ELISA Kit - E14436m from ARP American Research Products Category ELISA Kit Prices $736.00 Sizes 96 t

Nanog homeobox, ELISA Kit - MBS2602965 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.5 ng/ml. Range 100 ng/ml-1.56 ng/ml

ELISA Kit for NANOG Homeobox Protein (NANOG) - SEJ992Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.064ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse NANOG Homeobox Protein (NANOG) ELISA Kit - EKU09286 from Biomatik Category ELISA Kit Prices $756.00, $3,326.00, $6,048.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.064 ng/mL Range 0.156-10 ng/mL

Mouse Nanog ELISA Kit - E055996 from Biobool Category ELISA Kit

NANOG ELISA Kit (Mouse) (OKCD02749) - OKCD02749 from Aviva Systems Biology Category ELISA Kit Prices $555.00 Sizes 10 ng Sensitivity 0.064 ng/mL Range 0.156-10 ng/mL

Mouse NANOG Homeobox protein (NANOG) ELISA Kit - AE31764MO from ARP American Research Products Category ELISA Kit Prices $612.00 Sizes 96 t

Homeobox protein NANOG, ELISA Kit - MBS2885163 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more