| Gene Symbol | Nanog |
|---|---|
| Entrez Gene | 71950 |
| Alt Symbol | 2410002E02Rik, ENK, ecat4 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | Nanog homeobox |
| Other Description | ES cell-associated protein 4|early embryo specific expression NK family|early embryo specific expression NK-type homeobox protein|homeobox protein NANOG|homeobox transcription factor Nanog |
| Swissprots | Q7TN85 Q80Z64 Q6SMR1 Q5TM83 |
| Accessions | ABD16123 ABD16124 CAH25963 EDK99694 Q5TM83 Q80Z64 AB093574 BAC76998 AB126939 BAD72892 AF507043 AAO67362 AK010332 BAE43219 AK167259 AY278951 AAP92157 AY455282 AAS57554 AY455285 AAS57556 BC083105 BC132017 AAI32018 BC137873 AAI37874 BC144995 AAI44996 BC144996 AAI44997 BY382803 XM_006506651 XP_006506714 XM_011241471 XP_011239773 XM_011241472 XP_011239774 XM_011241473 XP_011239775 NM_001289828 NP_001276757 NM_001289830 NP_001276759 NM_001289831 NP_001276760 NM_028016 NP_082292 |
| Function | Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
| Top Pathways | Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer |
Nanog CRISPR/Cas9 KO Plasmid (m) - sc-428155 from Santa Cruz Biotechnology
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Nanog HDR Plasmid (m) - sc-428155-HDR from Santa Cruz Biotechnology
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Nanog Double Nickase Plasmid (m) - sc-428155-NIC from Santa Cruz Biotechnology
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Nanog Double Nickase Plasmid (m2) - sc-428155-NIC-2 from Santa Cruz Biotechnology
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Nanog CRISPR Activation Plasmid (m) - sc-428155-ACT from Santa Cruz Biotechnology
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Nanog CRISPR Activation Plasmid (m2) - sc-428155-ACT-2 from Santa Cruz Biotechnology
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Nanog Lentiviral Activation Particles (m) - sc-428155-LAC from Santa Cruz Biotechnology
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Nanog Lentiviral Activation Particles (m2) - sc-428155-LAC-2 from Santa Cruz Biotechnology
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Nanog siRNA (m) - sc-44833 from Santa Cruz Biotechnology
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Nanog shRNA Plasmid (m) - sc-44833-SH from Santa Cruz Biotechnology
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Nanog shRNA (m) Lentiviral Particles - sc-44833-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU183581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36185 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36185 from Sigma-Aldrich
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NANOG siRNA (Mouse) - CRM8620 from Cohesion Biosciences
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Mouse NANOG siRNA - orb288096 from Biorbyt
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NANOG shRNA Plasmid (Mouse) - CHM8620 from Cohesion Biosciences
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