Nanog

Gene Symbol Nanog
Entrez Gene 71950
Alt Symbol 2410002E02Rik, ENK, ecat4
Species Mouse
Gene Type protein-coding
Description Nanog homeobox
Other Description ES cell-associated protein 4|early embryo specific expression NK family|early embryo specific expression NK-type homeobox protein|homeobox protein NANOG|homeobox transcription factor Nanog
Swissprots Q7TN85 Q80Z64 Q6SMR1 Q5TM83
Accessions ABD16123 ABD16124 CAH25963 EDK99694 Q5TM83 Q80Z64 AB093574 BAC76998 AB126939 BAD72892 AF507043 AAO67362 AK010332 BAE43219 AK167259 AY278951 AAP92157 AY455282 AAS57554 AY455285 AAS57556 BC083105 BC132017 AAI32018 BC137873 AAI37874 BC144995 AAI44996 BC144996 AAI44997 BY382803 XM_006506651 XP_006506714 XM_011241471 XP_011239773 XM_011241472 XP_011239774 XM_011241473 XP_011239775 NM_001289828 NP_001276757 NM_001289830 NP_001276759 NM_001289831 NP_001276760 NM_028016 NP_082292
Function Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'- [CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
Top Pathways Signaling pathways regulating pluripotency of stem cells, Proteoglycans in cancer

Recombinant Mouse Nanog, TAT-tagged - Nanog-151M from Creative Biomart

Category Protein
Source E. coli
Species Mouse

Recombinant Mouse Homeobox protein NANOG(Nanog) - CSB-YP800371MO CSB-EP800371MO CSB-BP800371MO CSB-MP800371MO from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Recombinant Mus musculus molossinus Homeobox protein NANOG(Nanog) - CSB-YP722589MUX CSB-EP722589MUX CSB-BP722589MUX CSB-MP722589MUX from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Mouse

Nanog, Peptide - MBS428233 from MyBioSource

Category Peptide
Prices $175.00
Sizes 100 µg
Species Mouse

Homeobox protein NANOG (Nanog), Recombinant Protein - MBS1337004 from MyBioSource

Category Protein
Prices $1,065.00, $1,065.00, $1,290.00, $1,290.00, $1,660.00, $1,660.00, $2,125.00, $2,125.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Homeobox protein NANOG (Nanog), Recombinant Protein - MBS1333999 from MyBioSource

Category Protein
Prices $1,065.00, $1,065.00, $1,290.00, $1,290.00, $1,660.00, $1,660.00, $2,125.00, $2,125.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse
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