| Gene Symbol |
PRDM5
|
| Entrez Gene |
11107
|
| Alt Symbol |
BCS2, PFM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PR domain containing 5
|
| Other Description |
PR domain zinc finger protein 5
|
| Swissprots |
Q9NQX1 Q0VAI9 Q0VAJ0 Q6NXQ7
|
| Accessions |
CCO13795 EAX05267 EAX05268 EAX05269 Q9NQX1 AF272897 AAF78077 AK056352 BAG51686 AK310958 AK314293 AW341546 BC047115 BC066942 AAH66942 BC121037 AAI21038 BC121038 AAI21039 BM563688 BX646150 XM_005262708 XP_005262765 XM_011531562 XP_011529864 XM_011531563 XP_011529865 XM_011531564 XP_011529866 XM_011531565 XP_011529867 XM_011531566 XP_011529868 XM_011531567 XP_011529869 XM_011531568 XP_011529870 XM_011531569 XP_011529871 XM_011531570 XP_011529872 XR_938677 XR_938678 XR_938679 XR_938680 NM_001300823 NP_001287752 NM_001300824 NP_001287753 NM_018699 NP_061169
|
| Function |
Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May caused G2/M arrest and apoptosis in cancer cells. {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019, ECO:0000269|PubMed:21664999}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17636019}.
|
| Tissue Specificity |
Widely expressed with highest levels in colon and ovary. Tends to be silenced in breast, colorectal, gastric and liver cancer tissues. {ECO:0000269|PubMed:15077163, ECO:0000269|PubMed:17699856}.
|