RNF126

Gene Symbol RNF126
Entrez Gene 55658
Alt Symbol -
Species Human
Gene Type protein-coding
Description ring finger protein 126
Other Description E3 ubiquitin-protein ligase RNF126
Swissprots Q9BV68 Q9NWX1
Accessions AAC06149 EAW61167 EAW61168 EAW61169 EAW61170 EAW61171 EAW61172 EAW61173 Q9BV68 AK000559 BAA91254 AK289616 BAF82305 AL360265 CAB96178 BC001442 AAH01442 BC025374 AAH25374 BG773910 BM558139 BM810439 CA440294 XM_005259594 XP_005259651 NM_194460 NP_919442 NM_017876
Function E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
Tissue Specificity Highly expressed in liver and testis. {ECO:0000269|PubMed:23026136}.

RNF126 (C-1) - sc-376005 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RNF126 (C-1): sc-376005. Western blot analysis of RNF126 expression in Jurkat (A) and CCRF-CEM (B) whole cell lysates.

RNF126 (G-13) - sc-240831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RNF126 (H-106) - sc-135374 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RNF126 (H-106): sc-135374. Western blot analysis of RNF126 expression in NIH/3T3 (A), Jurkat (B), RAW 264.7 (C), PC-12 (D) and U-251 MG (E) whole cell lysates.

RNF126 (T-14) - sc-240832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RNF126 antibody - ab183102 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RNF126 antibody (ab183102) at 1/350 dilutionLane 1 : Jurkat cell lysateLane 2 : K562 cell lysateLysates/proteins at 40 µg per lane.SecondaryGoat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution

Anti-RNF126 antibody - ab87256 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-RNF126 antibody (ab87256) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-RNF126 Antibody (clone 3F11) - LS-C139236 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F11
RNF126 monoclonal antibody (M04), clone 3F11. Western blot of RNF126 expression in NIH/3T3.

Anti-RNF126 Antibody (aa71-120) - LS-C102009 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
RNF126 antibody LS-C102009 Western blot of Jurkat lysate.

RNF126 Antibody - NBP1-83645 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RNF126 Antibody [NBP1-83645] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.

RNF126 Antibody - NBP1-55058 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126 Antibody (3F11) - H00055658-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F11

RNF126 Polyclonal Antibody - bs-2125R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human stomach labeled with Anti-RNF126 Polyclonal Antibody, Unconjugated (bs-2125R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

Anti-RNF126 antibody produced in rabbit - HPA043050 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RNF126: <B>Cat. No. HPA043050</B>: Immunohistochemical staining of human thyroid gland shows moderate cytoplasmic positivity in glandular cells.

Anti-RNF126 (113-125) antibody produced in rabbit - SAB1104363 from Sigma-Aldrich

Prices $285.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human RNF126 was separated on SDS-PAGE, blotted with Anti-RNF126 (113-125) (<B>Cat. No. SAB1104363</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250

Monoclonal Anti-RNF126 antibody produced in mouse - SAB1403298 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F11
<B>Immunoblotting</B><BR/>Monoclonal Anti-RNF126: <B>Cat. No. SAB1403298</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~35.6 kDa using NIH/3T3 lysate.

Anti-RNF126, (N-terminal) antibody produced in rabbit - SAB2103327 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-RNF126, antibody produced in rabbit: <B>Cat. No. SAB2103327</B>: Immunoblotting analysis of RNF126 in Jurkat cell lysate with RNF126 anitbody at 1 μg/mL.

Anti-RNF126 (56-70) antibody produced in rabbit - SAB1104362 from Sigma-Aldrich

Prices $285.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human RNF126 was separated on SDS-PAGE, blotted with Anti-RNF126 (56-70) (<B>Cat. No. SAB1104362</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + RNF126 immunizing peptide (human, 56-70)

RNF126 antibody - N-terminal region (ARP43235_P050) - ARP43235_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126-Antibody-monoclonal-M04 - AT3662a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F11
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (61.6 KDa) .

RNF126 antibody - 70R-2800 from Fitzgerald

Prices $345.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

RNF126 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-2125R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-2125R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-2125R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-2125R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

RNF126 Polyclonal Antibody, Cy3 Conjugated - bs-2125R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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