RNF126

Gene Symbol RNF126
Entrez Gene 55658
Alt Symbol -
Species Human
Gene Type protein-coding
Description ring finger protein 126
Other Description E3 ubiquitin-protein ligase RNF126
Swissprots Q9BV68 Q9NWX1
Accessions AAC06149 EAW61167 EAW61168 EAW61169 EAW61170 EAW61171 EAW61172 EAW61173 Q9BV68 AK000559 BAA91254 AK289616 BAF82305 AL360265 CAB96178 BC001442 AAH01442 BC025374 AAH25374 BG773910 BM558139 BM810439 CA440294 XM_005259594 XP_005259651 NM_194460 NP_919442 NM_017876
Function E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (
Subcellular Location Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
Tissue Specificity Highly expressed in liver and testis. {ECO:0000269|PubMed:23026136}.

RNF126 CRISPR/Cas9 KO Plasmid (h) - sc-405024 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 HDR Plasmid (h) - sc-405024-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 Double Nickase Plasmid (h) - sc-405024-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 Double Nickase Plasmid (h2) - sc-405024-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 CRISPR Activation Plasmid (h) - sc-405024-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 CRISPR Activation Plasmid (h2) - sc-405024-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 Lentiviral Activation Particles (h) - sc-405024-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 Lentiviral Activation Particles (h2) - sc-405024-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RNF126 siRNA (h) - sc-97281 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF126 shRNA Plasmid (h) - sc-97281-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF126 shRNA (h) Lentiviral Particles - sc-97281-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RNF126 RNAi - H00055658-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

RNF126 RNAi - H00055658-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU061941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18376 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18376 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05257 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05257

RNF126 siRNA (Human) - CRJ0810 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF126 - MBS8217682 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RNF126 (NM_194460.2) - SHH396656 from Creative biogene

Category siRNA
Species Reactivities Human

Human RNF126 siRNA - orb271311 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RNF126 shRNA Plasmid (Human) - CHJ0810 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RNF126 miRNA 3'UTR clone - MiUTR3H-15917 from Creative biogene

Species Reactivities Human
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