| Gene Symbol |
RNF126
|
| Entrez Gene |
55658
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 126
|
| Other Description |
E3 ubiquitin-protein ligase RNF126
|
| Swissprots |
Q9BV68 Q9NWX1
|
| Accessions |
AAC06149 EAW61167 EAW61168 EAW61169 EAW61170 EAW61171 EAW61172 EAW61173 Q9BV68 AK000559 BAA91254 AK289616 BAF82305 AL360265 CAB96178 BC001442 AAH01442 BC025374 AAH25374 BG773910 BM558139 BM810439 CA440294 XM_005259594 XP_005259651 NM_194460 NP_919442 NM_017876
|
| Function |
E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
|
| Tissue Specificity |
Highly expressed in liver and testis. {ECO:0000269|PubMed:23026136}.
|