RNF126

Gene Symbol	RNF126
Entrez Gene	55658
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	ring finger protein 126
Other Description	E3 ubiquitin-protein ligase RNF126
Swissprots	Q9BV68 Q9NWX1
Accessions	AAC06149 EAW61167 EAW61168 EAW61169 EAW61170 EAW61171 EAW61172 EAW61173 Q9BV68 AK000559 BAA91254 AK289616 BAF82305 AL360265 CAB96178 BC001442 AAH01442 BC025374 AAH25374 BG773910 BM558139 BM810439 CA440294 XM_005259594 XP_005259651 NM_194460 NP_919442 NM_017876
Function	E3 ubiquitin-protein ligase that regulates several biological processes through ubiquitination of various target proteins. Depending on the associated E2 ligase, mediates 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of substrates. Through their polyubiquitination, may play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4. May also be part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. May provide the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the mislocalized proteins and their targeting to the proteasome (PubMed:24981174). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (PubMed:24275455). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:23026136}. Nucleus {ECO:0000269|PubMed:23026136}.
Tissue Specificity	Highly expressed in liver and testis. {ECO:0000269|PubMed:23026136}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF126 full length protein - ab163167 from Abcam Category Protein Source Wheat germ Species Human

RNF126 Antibody Blocking Peptide - LS-E15908 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF126 Protein - H00055658-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF126-Antibody-N-term-Blocking-Peptide - BP19470a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF126 Blocking Peptide - 33R-3774 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF126 - H00055658-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF126 - H00055658-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF126 fusion protein - Ag13816 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RNF126, His-tagged - RNF126-2335H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human RING finger protein 126(RNF126) - CSB-YP019828HU CSB-EP019828HU CSB-BP019828HU CSB-MP019828HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF126 Peptide - abx164853 from Abbexa Category Peptide Species Human, Rat

RNF126 Recombinant Protein Antigen - NBP1-83645PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF126-Blocking-Peptide-Center - BP21884c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF126 Peptide, Human - M34GP13378H from Creative Peptides Category Peptide Source Synthetic. Species Human

RING finger protein 126 (RNF126), Recombinant Protein - MBS1314045 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,705.00, $1,705.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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