| Gene Symbol |
TRIM71
|
| Entrez Gene |
131405
|
| Alt Symbol |
LIN-41, LIN41
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 71, E3 ubiquitin protein ligase
|
| Other Description |
E3 ubiquitin-protein ligase TRIM71|abnormal cell LINeage LIN-41|homolog of C. elegans Lin-41|protein lin-41 homolog|tripartite motif-containing 71|tripartite motif-containing protein 71
|
| Swissprots |
Q2Q1W2
|
| Accessions |
Q2Q1W2 BC156152 AAI56153 BC157052 AAI57053 DQ232881 ABB18374 NM_001039111 NP_001034200
|
| Function |
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, P-body {ECO:0000250}.
|
| Tissue Specificity |
Specifically expressed in testis. {ECO:0000269|PubMed:15722555}.
|
| Top Pathways |
MicroRNAs in cancer
|