Gene Symbol | TRIM71 |
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Entrez Gene | 131405 |
Alt Symbol | LIN-41, LIN41 |
Species | Human |
Gene Type | protein-coding |
Description | tripartite motif containing 71, E3 ubiquitin protein ligase |
Other Description | E3 ubiquitin-protein ligase TRIM71|abnormal cell LINeage LIN-41|homolog of C. elegans Lin-41|protein lin-41 homolog|tripartite motif-containing 71|tripartite motif-containing protein 71 |
Swissprots | Q2Q1W2 |
Accessions | Q2Q1W2 BC156152 AAI56153 BC157052 AAI57053 DQ232881 ABB18374 NM_001039111 NP_001034200 |
Function | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, P-body {ECO:0000250}. |
Tissue Specificity | Specifically expressed in testis. {ECO:0000269|PubMed:15722555}. |
Top Pathways | MicroRNAs in cancer |
Human TRIM71 full length protein - ab153596 from Abcam
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LIN41 / TRIM71 Antibody Blocking Peptide - LS-E27313 from LifeSpan Bioscience
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LIN41 / TRIM71 Antibody Blocking Peptide - LS-E27314 from LifeSpan Bioscience
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LIN41 / TRIM71 Antibody Blocking Peptide - LS-E30980 from LifeSpan Bioscience
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LIN-41/TRIM71 Blocking Peptide - NBP1-76281PEP from Novus Biologicals
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TRIM71 (aa390-402) blocking peptide - GTX88128-PEP from GeneTex
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TRIM71 (aa409-419) blocking peptide - GTX88194-PEP from GeneTex
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TRIM71 Peptide - GTX85001-PEP from GeneTex
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TRIM71 Immunizing peptide - orb17807 from Biorbyt
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TRIM71 Blocking Peptide - 33R-10678 from Fitzgerald
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TRIM71 Peptide - AC21-2136-P from Abcore
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TRIM71 Peptide - AC21-2137-P from Abcore
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TRIM71 - H00131405-P01-10 from Acris Antibodies
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TRIM71 - H00131405-P01-25 from Acris Antibodies
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TRIM71 control peptide - AP26252CP-N from Acris Antibodies
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TRIM71 Peptide - 42-540P from ProSci
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TRIM71 Peptide - 5881P from ProSci
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TRIM71 Peptide - 42-541P from ProSci
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Recombinant Human Tripartite motif-containing protein 71(TRIM71) ,partial - CSB-YP652403HU CSB-EP652403HU CSB-BP652403HU CSB-MP652403HU from Cusabio
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TRIM71 Blocking Peptide - 3241BP-50 from Biovision
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TRIM71, Peptide - MBS843578 from MyBioSource
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TRIM71, Peptide - MBS428225 from MyBioSource
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TRIM71, Peptide - MBS427230 from MyBioSource
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LIN-41/TRIM71 Recombinant Protein Antigen - NBP1-81306PEP from Novus Biologicals
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LIN-41/TRIM71 Protein - NBP2-34043PEP from Novus Biologicals
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