TRIM13

Gene Symbol TRIM13
Entrez Gene 10206
Alt Symbol CAR, DLEU5, LEU5, RFP2, RNF77
Species Human
Gene Type protein-coding
Description tripartite motif containing 13
Other Description B-cell chronic lymphocytic leukemia tumor suppressor Leu5|CLL-associated RING finger|E3 ubiquitin-protein ligase TRIM13|RING finger protein 77|leukemia-associated protein 5|putative tumor suppressor RFP2|ret finger protein 2|tripartite motif protein 13|tripartite motif-containing 13|tripartite motif-containing protein 13
Swissprots B2RB49 Q5UBW0 Q5W0U9 Q9BQ47 Q5W0U8 O60858 Q9C021
Accessions AAK13059 AAK51624 CBH19816 CCQ43336 EAX08844 EAX08845 EAX08846 EAX08847 EAX08848 O60858 AF220127 AAG53500 AF220128 AAG53501 AF241850 AAF91315 AJ224819 CAA12136 AK001806 AK056841 AK314496 BAG37096 AL360196 AL832695 CAD38633 AY191002 AAO38979 AY455758 AAR31110 AY764035 AAV51406 BC003579 AAH03579 BC029514 BC055420 BC063407 AAH63407 BI668033 DQ892570 ABM83496 DQ895785 ABM86711 NM_001007278 NP_001007279 NM_005798 NP_005789 NM_052811 NP_434698 NM_213590 NP_998755
Function E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}; Single-pass membrane protein {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.

Rfp2 (A-2) - sc-398129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rfp2 (A-2): sc-398129. Western blot analysis of Rfp2 expression in IMR-32 whole cell lysate.

Rfp2 (E-6) - sc-393257 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rfp2 (E-6): sc-393257. Western blot analysis of Rfp2 expression in NTERA-2 cl.D1 whole cell lysate.

Rfp2 (G-18) - sc-69605 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Rfp2 (G-18): sc-69605. Western blot analysis of Rfp2 expression in HEK293 (A) and IMR-32 (B) whole cell lysates and mouse embryo (C) and mouse lymph node (D) tissue extracts.

Rfp2 (N-15) - sc-69606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Rfp2 (N-15): sc-69606. Western blot analysis of Rfp2 expression in HEK293 (A), IMR-32 (B) and SK-N-MC (C) whole cell lysates and mouse embryo (D) and mouse lymph node (E) tissue extracts.

Rfp2 (H-300) - sc-98606 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Rfp2 (T-23) - sc-133953 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Rfp2 (T-23): sc-133953. Western blot analysis of Rfp2 expression in Jurkat whole cell lysate.

Anti-RFP2 antibody - ab5515 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Left: Endogenous RFP2Top: DAPIBottom: ab5515Detection using indirect fluorescence of the signal corresponding to endogenous RFP2in 293T cells. Cells fixed using 4% formaldehyde, blocked with PBS containing 3% milk and 0.5% Triton X-100, incubated for 1 hour at 37 °C using a 1/50 dilution of antibody ab5515. Cells were then washed 3 times and incubated for 1 hour at 37 °C with a goat anti-rabbit secondary antibody (1/500 dilution) coupled to Alexa Fluor 555 (Molecular Probes). Following 3 more washes, cells were stained with DAPI and mounted with Vectashield.Right: Overexpressed RFP2Top: anti-FLAG antibodyMiddle: ab5515Bottom: Merge of anti-FLAG and ab5515 (and DAPI) staining.Detection using indirect fluorescence of the signal corresponding to staining with anti-FLAG mouse antibody (top) and antibody ab5515 against RFP2(middle) in 293T cells. 293T cells were transfected with vectors for overexpression of flagged RFP2 u

Anti-TRIM13 Antibody (aa61-90, AP) - LS-C272162 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa61-90, APC) - LS-C272163 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa61-90, Biotin) - LS-C272164 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa181-230) - LS-C30972 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-TRIM13 Antibody (aa61-90, FITC) - LS-C272165 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa61-90, Azide-free, HRP) - LS-C272166 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa61-90, PE) - LS-C272167 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa60-90) - LS-C325930 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody - LS-C136877 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa51-100) - LS-C80121 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 2.5 ug/ml. Gel concentration: 12%.

Anti-TRIM13 Antibody - LS-C341979 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TRIM13 Antibody (aa74-123) - LS-C80119 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TRIM13 Antibody (aa61-90) - LS-C157268 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRIM13 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The TRIM13 antibody detected the TRIM13 protein (arrow).

Anti-TRIM13 Antibody - LS-C346104 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of HeLa cell using TRIM13 antibody. Blue: DAPI for nuclear staining.

Anti-TRIM13 Antibody (aa165-214) IHC-plus™ - LS-B1007 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RFP2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1007 concentration 5 ug/ml.

TRIM13 Antibody - NBP1-85016 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: TRIM13 Antibody [NBP1-85016] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

TRIM13 Antibody - H00010206-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: TRIM13 Antibody [H00010206-A01] - RFP2 polyclonal antibody (A01), Lot # UYL6060127QCS1 Western Blot analysis of RFP2 expression in HeLa ( Cat # L013V1 ).

TRIM13 Antibody (1E5) - H00010206-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1E5
Sandwich ELISA: TRIM13 Antibody (1E5) [H00010206-M02] - Detection limit for recombinant GST tagged TRIM13 is 1 ng/ml as a capture antibody.
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