| Gene Symbol |
TRIM13
|
| Entrez Gene |
10206
|
| Alt Symbol |
CAR, DLEU5, LEU5, RFP2, RNF77
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tripartite motif containing 13
|
| Other Description |
B-cell chronic lymphocytic leukemia tumor suppressor Leu5|CLL-associated RING finger|E3 ubiquitin-protein ligase TRIM13|RING finger protein 77|leukemia-associated protein 5|putative tumor suppressor RFP2|ret finger protein 2|tripartite motif protein 13|tripartite motif-containing 13|tripartite motif-containing protein 13
|
| Swissprots |
B2RB49 Q5UBW0 Q5W0U9 Q9BQ47 Q5W0U8 O60858 Q9C021
|
| Accessions |
AAK13059 AAK51624 CBH19816 CCQ43336 EAX08844 EAX08845 EAX08846 EAX08847 EAX08848 O60858 AF220127 AAG53500 AF220128 AAG53501 AF241850 AAF91315 AJ224819 CAA12136 AK001806 AK056841 AK314496 BAG37096 AL360196 AL832695 CAD38633 AY191002 AAO38979 AY455758 AAR31110 AY764035 AAV51406 BC003579 AAH03579 BC029514 BC055420 BC063407 AAH63407 BI668033 DQ892570 ABM83496 DQ895785 ABM86711 NM_001007278 NP_001007279 NM_005798 NP_005789 NM_052811 NP_434698 NM_213590 NP_998755
|
| Function |
E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}; Single-pass membrane protein {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.
|