TRIM13

Gene Symbol	TRIM13
Entrez Gene	10206
Alt Symbol	CAR, DLEU5, LEU5, RFP2, RNF77
Species	Human
Gene Type	protein-coding
Description	tripartite motif containing 13
Other Description	B-cell chronic lymphocytic leukemia tumor suppressor Leu5|CLL-associated RING finger|E3 ubiquitin-protein ligase TRIM13|RING finger protein 77|leukemia-associated protein 5|putative tumor suppressor RFP2|ret finger protein 2|tripartite motif protein 13|tripartite motif-containing 13|tripartite motif-containing protein 13
Swissprots	B2RB49 Q5UBW0 Q5W0U9 Q9BQ47 Q5W0U8 O60858 Q9C021
Accessions	AAK13059 AAK51624 CBH19816 CCQ43336 EAX08844 EAX08845 EAX08846 EAX08847 EAX08848 O60858 AF220127 AAG53500 AF220128 AAG53501 AF241850 AAF91315 AJ224819 CAA12136 AK001806 AK056841 AK314496 BAG37096 AL360196 AL832695 CAD38633 AY191002 AAO38979 AY455758 AAR31110 AY764035 AAV51406 BC003579 AAH03579 BC029514 BC055420 BC063407 AAH63407 BI668033 DQ892570 ABM83496 DQ895785 ABM86711 NM_001007278 NP_001007279 NM_005798 NP_005789 NM_052811 NP_434698 NM_213590 NP_998755
Function	E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}; Single-pass membrane protein {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RFP2 full length protein - ab131979 from Abcam Category Protein Source Wheat germ Species Human

Human RFP2 peptide - ab24397 from Abcam Category Peptide

TRIM13 Antibody Blocking Peptide - LS-E2327 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM13 Antibody Blocking Peptide - LS-E12077 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM13 Antibody Blocking Peptide - LS-E12076 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM13 Antibody Blocking Peptide - LS-E12631 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIM13 Antibody Blocking Peptide - LS-E12654 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TRIM13 Protein - H00010206-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

TRIM13 Recombinant Protein - H00010206-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRIM13-Antibody-N-term-Blocking-peptide - BP13285a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RFP2 Blocking Peptide - 33R-4710 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RFP2 Blocking Peptide - 33R-2197 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRIM13 / RNF77 - H00010206-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

TRIM13 / RNF77 - H00010206-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

TRIM13 / RNF77 - H00010206-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRIM13 / RNF77 - H00010206-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRIM13 fusion protein - ag13993 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TRIM13 fusion protein - Ag16805 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TRIM13 / RNF77 (transcript variant 3) - TP309480 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

TRIM13 Recombinant Protein Antigen - NBP1-85016PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRIM13 Peptide, Human - M34GP16566H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase TRIM13 (TRIM13), Recombinant Protein - MBS1140514 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

E3 ubiquitin-protein ligase TRIM13 (TRIM13), Recombinant Protein - MBS7032177 from MyBioSource Category Protein Prices $1,210.00, $2,195.00, $3,405.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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