| Gene Symbol |
POU2AF1
|
| Entrez Gene |
5450
|
| Alt Symbol |
BOB1, OBF-1, OBF1, OCAB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
POU class 2 associating factor 1
|
| Other Description |
B-cell-specific coactivator OBF-1|BOB-1|OCA-B|OCT-binding factor 1|POU domain class 2-associating factor 1|POU domain, class 2, associating factor 1
|
| Swissprots |
Q14983 B2R8Z9 Q16633
|
| Accessions |
AAB34937 CBX47639 EAW67137 Q16633 AK313573 BAG36346 BC032549 AAH32549 DQ890869 ABM81795 EU176491 ABW03292 X83504 CAA58494 Z47550 CAA87630 Z49194 CAA89053 XM_005271593 XP_005271650 XM_005271594 XP_005271651 XM_006718859 XP_006718922 XM_006718860 XP_006718923 NM_006235 NP_006226
|
| Function |
Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
B-cell specific.
|
