Gene Symbol | POU2AF1 |
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Entrez Gene | 5450 |
Alt Symbol | BOB1, OBF-1, OBF1, OCAB |
Species | Human |
Gene Type | protein-coding |
Description | POU class 2 associating factor 1 |
Other Description | B-cell-specific coactivator OBF-1|BOB-1|OCA-B|OCT-binding factor 1|POU domain class 2-associating factor 1|POU domain, class 2, associating factor 1 |
Swissprots | Q14983 B2R8Z9 Q16633 |
Accessions | AAB34937 CBX47639 EAW67137 Q16633 AK313573 BAG36346 BC032549 AAH32549 DQ890869 ABM81795 EU176491 ABW03292 X83504 CAA58494 Z47550 CAA87630 Z49194 CAA89053 XM_005271593 XP_005271650 XM_005271594 XP_005271651 XM_006718859 XP_006718922 XM_006718860 XP_006718923 NM_006235 NP_006226 |
Function | Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. |
Subcellular Location | Nucleus. |
Tissue Specificity | B-cell specific. |
Bob 1 CRISPR/Cas9 KO Plasmid (h) - sc-400771 from Santa Cruz Biotechnology
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Bob 1 HDR Plasmid (h) - sc-400771-HDR from Santa Cruz Biotechnology
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Bob 1 Double Nickase Plasmid (h) - sc-400771-NIC from Santa Cruz Biotechnology
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Bob 1 Double Nickase Plasmid (h2) - sc-400771-NIC-2 from Santa Cruz Biotechnology
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Bob 1 CRISPR Activation Plasmid (h) - sc-400771-ACT from Santa Cruz Biotechnology
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Bob 1 CRISPR Activation Plasmid (h2) - sc-400771-ACT-2 from Santa Cruz Biotechnology
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Bob 1 Lentiviral Activation Particles (h) - sc-400771-LAC from Santa Cruz Biotechnology
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Bob 1 Lentiviral Activation Particles (h2) - sc-400771-LAC-2 from Santa Cruz Biotechnology
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Bob 1 siRNA (h) - sc-29818 from Santa Cruz Biotechnology
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Bob 1 shRNA Plasmid (h) - sc-29818-SH from Santa Cruz Biotechnology
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Bob 1 shRNA (h) Lentiviral Particles - sc-29818-V from Santa Cruz Biotechnology
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BOB1 RNAi - H00005450-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN17173 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17173 from Sigma-Aldrich
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POU2AF1 siRNA (Human) - CRH3652 from Cohesion Biosciences
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Bob 1 CRISPR/Cas9 KO Plasmid (h2) - sc-400771-KO-2 from Santa Cruz Biotechnology
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Bob 1 HDR Plasmid (h2) - sc-400771-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human POU2AF1 (NM_006235.2) - SHH380016 from Creative biogene
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shRNA set against Human POU2AF1(NM_006235.2) - SHR129612 from Creative biogene
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Human POU2AF1 siRNA - orb264154 from Biorbyt
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POU2AF1 shRNA Plasmid (Human) - CHH3652 from Cohesion Biosciences
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POU2AF1 miRNA 3'UTR clone - MiUTR1H-08111 from Creative biogene
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