Gene Symbol | POU2AF1 |
---|---|
Entrez Gene | 5450 |
Alt Symbol | BOB1, OBF-1, OBF1, OCAB |
Species | Human |
Gene Type | protein-coding |
Description | POU class 2 associating factor 1 |
Other Description | B-cell-specific coactivator OBF-1|BOB-1|OCA-B|OCT-binding factor 1|POU domain class 2-associating factor 1|POU domain, class 2, associating factor 1 |
Swissprots | Q14983 B2R8Z9 Q16633 |
Accessions | AAB34937 CBX47639 EAW67137 Q16633 AK313573 BAG36346 BC032549 AAH32549 DQ890869 ABM81795 EU176491 ABW03292 X83504 CAA58494 Z47550 CAA87630 Z49194 CAA89053 XM_005271593 XP_005271650 XM_005271594 XP_005271651 XM_006718859 XP_006718922 XM_006718860 XP_006718923 NM_006235 NP_006226 |
Function | Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers. |
Subcellular Location | Nucleus. |
Tissue Specificity | B-cell specific. |