| Gene Symbol |
FLVCR1
|
| Entrez Gene |
28982
|
| Alt Symbol |
AXPC1, FLVCR, MFSD7B, PCA, PCARP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
feline leukemia virus subgroup C cellular receptor 1
|
| Other Description |
feline leukemia virus subgroup C receptor-related protein 1
|
| Swissprots |
Q9NVR9 Q9Y5Y0 Q1HE16 Q86XY9
|
| Accessions |
ABF47096 EAW93374 Q9Y5Y0 AF118637 AAD45243 AK001419 BAA91679 AK090739 AK314481 BAG37085 BC048312 AAH48312 BE088852 BY800024 GD138340 XM_011509446 XP_011507748 XM_011509447 XP_011507749 XM_011509448 XP_011507750 XR_247024 XR_426771 XR_426772 XR_921769 NM_014053 NP_054772
|
| Function |
Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. {ECO:0000269|PubMed:10400745}.
|
