FLVCR1

Gene Symbol FLVCR1
Entrez Gene 28982
Alt Symbol AXPC1, FLVCR, MFSD7B, PCA, PCARP
Species Human
Gene Type protein-coding
Description feline leukemia virus subgroup C cellular receptor 1
Other Description feline leukemia virus subgroup C receptor-related protein 1
Swissprots Q9NVR9 Q9Y5Y0 Q1HE16 Q86XY9
Accessions ABF47096 EAW93374 Q9Y5Y0 AF118637 AAD45243 AK001419 BAA91679 AK090739 AK314481 BAG37085 BC048312 AAH48312 BE088852 BY800024 GD138340 XM_011509446 XP_011507748 XM_011509447 XP_011507749 XM_011509448 XP_011507750 XR_247024 XR_426771 XR_426772 XR_921769 NM_014053 NP_054772
Function Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.
Subcellular Location Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. {ECO:0000269|PubMed:10400745}.

FLVCR (C-4) - sc-390100 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
FLVCR (C-4): sc-390100. Western blot analysis of FLVCR expression in HEL 92.1.7 (A) and MIA PaCa-2 (B) whole cell lysates.

FLVCR (C-16) - sc-55646 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

FLVCR (H-120) - sc-134920 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FLVCR (H-120): sc-134920. Western blot analysis of FLVCR expression in mouse colon tissue extract.

FLVCR (M-115) - sc-134921 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
FLVCR (M-115): sc-134921. Western blot analysis of FLVCR expression in HeLa (A), NIH/3T3 (B), K-562 (C) and M1 (D) whole cell lysates.

FLVCR (T-12) - sc-55648 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-FLVCR antibody - ab70838 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of FLVCR staining in Human breast adenocarcinoma formalin fixed paraffin embedded tissue section, performed on a Leica Bond™ system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab70838, 1µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-FLVCR antibody - ab57317 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57317 FLVCR antibody at 1ug/ml.

Anti-FLVCR / FLVCR1 Antibody (aa1-84) - LS-C307578 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FLVCR / FLVCR1 Antibody - LS-C310375 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLVCR / FLVCR1 Antibody (aa223-272) - LS-C145390 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FLVCR1 / FLVCR antibody LS-C145390 Western blot of Mouse Brain lysate. Antibody concentration 1 ug/ml.

Anti-FLVCR / FLVCR1 Antibody (aa543-555) - LS-C54846 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (0.1 ug/ml) staining of Human Bone Marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FLVCR / FLVCR1 Antibody (aa505-555) - LS-C291063 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human FLVCR1 by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP; 20% of IP loaded) prepared using NETN buffer from 293T cells. Antibodies: Affinity purified rabbit anti-FLVCR1 antibody used for IP at 6 ug per reaction. FLVCR1 was also immunoprecipitated by rabbit anti-FLVCR1 antibody BL16474. For blotting immunoprecipitated FLVCR1, was used at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

FLVCR Antibody - NB100-1481 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: FLVCR Antibody [NB100-1481] - (0.1ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

FLVCR Antibody - NBP2-36564 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FLVCR Antibody [NBP2-36564] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-FLVCR1 antibody used for WB at 0.4 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

FLVCR Antibody (4B2) - H00028982-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B2

FLVCR Antibody - NBP2-14019 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Antibody - NBP2-16509 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: FLVCR Antibody [NBP2-16509] - Western Blot analysis of FLVCR1 expression in transfected 293T cell line by FLVCR1 polyclonal antibody. A: Non-transfected lysate. B: FLVCR1 transfected lysate. 7. 5% SDS PAGE gel, diluted at 1:500.

FLVCR Antibody - H00028982-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: FLVCR Antibody [H00028982-B01] - analysis of FLVCR expression in transfected 293T cell line by FLVCR MaxPab polyclonal antibody (B01). Lane 1: FLVCR transfected lysate (59.90 KDa). Lane 2: Non-transfected lysate.

FLVCR Antibody - H00028982-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: FLVCR Antibody [H00028982-D01P] - analysis of FLVCR1 expression in transfected 293T cell line by FLVCR1 MaxPab rabbit polyclonal antibody. Lane 1: FLVCR1 transfected lysate (59.90 KDa). Lane 2: Non-transfected lysate.

FLVCR Polyclonal Antibody - bs-12344R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-12344R-A350 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-12344R-A488 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-12344R-A555 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-12344R-A647 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

FLVCR Polyclonal Antibody, Cy3 Conjugated - bs-12344R-Cy3 from Bioss

Prices $369.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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