FLVCR1

Gene Symbol FLVCR1
Entrez Gene 28982
Alt Symbol AXPC1, FLVCR, MFSD7B, PCA, PCARP
Species Human
Gene Type protein-coding
Description feline leukemia virus subgroup C cellular receptor 1
Other Description feline leukemia virus subgroup C receptor-related protein 1
Swissprots Q9NVR9 Q9Y5Y0 Q1HE16 Q86XY9
Accessions ABF47096 EAW93374 Q9Y5Y0 AF118637 AAD45243 AK001419 BAA91679 AK090739 AK314481 BAG37085 BC048312 AAH48312 BE088852 BY800024 GD138340 XM_011509446 XP_011507748 XM_011509447 XP_011507749 XM_011509448 XP_011507750 XR_247024 XR_426771 XR_426772 XR_921769 NM_014053 NP_054772
Function Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and may be required to protect developing erythroid cells from heme toxicity. Heme export also provides protection from heme or ferrous iron toxicities in liver and brain. Causes susceptibility to FeLV-C in vitro. Required during erythtopoiesis to maintain intracellular free heme balance since in proerythroblasts, heme synthesis intensifies and it's accumulation is toxic for cells.
Subcellular Location Isoform 1: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Found all hematopoietic tissues including peripheral blood lymphocytes. Some expression is found in pancreas and kidney. {ECO:0000269|PubMed:10400745}.

FLVCR CRISPR/Cas9 KO Plasmid (h) - sc-408589 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR HDR Plasmid (h) - sc-408589-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR Double Nickase Plasmid (h) - sc-408589-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR Double Nickase Plasmid (h2) - sc-408589-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR CRISPR Activation Plasmid (h) - sc-408589-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR CRISPR Activation Plasmid (h2) - sc-408589-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR Lentiviral Activation Particles (h) - sc-408589-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR Lentiviral Activation Particles (h2) - sc-408589-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

FLVCR siRNA (h) - sc-62324 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLVCR shRNA Plasmid (h) - sc-62324-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLVCR shRNA (h) Lentiviral Particles - sc-62324-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

FLVCR RNAi - H00028982-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: FLVCR RNAi [H00028982-R01V] - Analysis of FLVCR over-expressed 293 cell line, cotransfected with FLVCR Validated Chimera RNAi or non-transfected control. Blot probed with H00028982-M05. GAPDH (36.1 kDa) used as loading control.

FLVCR RNAi - H00028982-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU017851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN8831 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02704 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr02704

FLVCR1 siRNA (Human) - CRH9145 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FLVCR1 - MBS8221350 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human FLVCR1 (NM_014053.3) - SHH295805 from Creative biogene

Category siRNA
Species Reactivities Human

Human FLVCR1 siRNA - orb269647 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FLVCR1 shRNA Plasmid (Human) - CHH9145 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FLVCR1 miRNA 3'UTR clone - MiUTR3H-10432 from Creative biogene

Species Reactivities Human
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